Figures & data
Figure 1. Effect of different concentrations of ginsenoside Rb1 on the inhibitory rate of human uterine fibroid cells. Note: *p < .05 compared with 0 μmol/L group; #p < .05 compared with 20 μmol/L group; &p < .05 compared with 40 μmol/L group.
Figure 2. Effect of ginsenoside Rb1 on apoptosis of human uterine fibroids. *p < .05.
Figure 3. Effect of ginsenoside Rb1 on the expression of HMGB1 in human uterine fibroid cells. (A) Effect of ginsenoside Rb1 on HMGB1 mRNA expression in human uterine fibroids; (B, C) effect of ginsenoside Rb1 on HMGB1 protein expression in human uterine fibroids. *p < .05.
Figure 4. Knockdown of HMGB1 inhibited HMGB1 expression in uterine fibroid cells. (A) Expression of mRNA in uterine fibroid cells after inhibition of HMGB1 expression; (B, C) expression of protein in uterine fibroid cells after inhibition of HMGB1 expression. *p < .05.
Figure 5. Effect of knockdown of HMGB1 expression on proliferation and apoptosis of uterine fibroid cells. (A) Inhibition of HMGB1 expression on proliferation of uterine fibroid cells; (B) effect of inhibition of HMGB1 expression on apoptosis of uterine fibroid cells. *p < .05.
Figure 6. Overexpression of HMGB1 reversed the inhibition of ginsenoside Rb1 on proliferation and the promotion of ginsenoside Rb1 on apoptosis of human uterine fibroid cells. (A, B) Expression of HMGB1 protein level; (C) overexpression of HMGB1 reversed the inhibitory effect of ginsenoside Rb1 on proliferation of human uterine fibroid cells; (D) overexpression of HMGB1 reversed the promotion effect of ginsenoside Rb1 on apoptosis of human uterine fibroid cells by ginsenoside Rb1. The promotion effect was compared with Con group, *p < .05; compared with Rb1 + pcDNA3.1 group, #p < .05.
