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Research Article

Poly-l-lactic acid scaffold incorporated chitosan-coated mesoporous silica nanoparticles as pH-sensitive composite for enhanced osteogenic differentiation of human adipose tissue stem cells by dexamethasone delivery

ORCID Icon, , , , , , ORCID Icon, , & show all
Pages 4020-4029 | Received 02 Feb 2019, Accepted 06 Jun 2019, Published online: 09 Oct 2019

Figures & data

Scheme 1. Schematic representation for the PLLA Scaffold incorporated MSN-Dexa@CS.

Scheme 1. Schematic representation for the PLLA Scaffold incorporated MSN-Dexa@CS.

Figure 1. FT-IR spectra of MSN (a) and calcinated MSN (b) (A), XRD pattern of MSN (a) and MSN@CS (b) after the removal of template (B), TGA Thermogram of CS coated MSN (C) and Standard calibration curve of Dexa in DI water (D).

Figure 1. FT-IR spectra of MSN (a) and calcinated MSN (b) (A), XRD pattern of MSN (a) and MSN@CS (b) after the removal of template (B), TGA Thermogram of CS coated MSN (C) and Standard calibration curve of Dexa in DI water (D).

Figure 2. FE-SEM images of MSNs-calcinated (a), MSN@CS (b), TEM images of MSNs-calcinated (c) and MSN@CS (d).

Figure 2. FE-SEM images of MSNs-calcinated (a), MSN@CS (b), TEM images of MSNs-calcinated (c) and MSN@CS (d).

Figure 3. SEM Picture of scaffolds: PLLA (a), MSN-Dexa@CS/PLLA Composite (b).

Figure 3. SEM Picture of scaffolds: PLLA (a), MSN-Dexa@CS/PLLA Composite (b).

Figure 4. Tensile strength graph of Pure PLLA and MSN-Dexa@CS/PLLA scaffolds.

Figure 4. Tensile strength graph of Pure PLLA and MSN-Dexa@CS/PLLA scaffolds.

Figure 5. Rate of cell proliferation of MSCs on different scaffolds and TCP (a), ALP activity of MSCs on different scaffolds and TCP (b) and Level of calcium deposition of MSCs on different scaffolds and TCP (c).

Figure 5. Rate of cell proliferation of MSCs on different scaffolds and TCP (a), ALP activity of MSCs on different scaffolds and TCP (b) and Level of calcium deposition of MSCs on different scaffolds and TCP (c).
Supplemental material

fiber_diameter_of_MSN-Dexa_CS-PLLA__b_.xls

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fiber_diameter_of_pure_PLLA__a_.xls

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