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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Coronaviruses

Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies

Xun Wanga State Key Laboratory of Genetic Engineering, Shanghai Institute of Infectious Disease and Biosecurity, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Xiaoyu Zhaoa State Key Laboratory of Genetic Engineering, Shanghai Institute of Infectious Disease and Biosecurity, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Jieyu Songb Department of Infectious Diseases, Huashan Hospital affiliated with Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Jing Wub Department of Infectious Diseases, Huashan Hospital affiliated with Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Yuqi Zhuc State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Minghui Lia State Key Laboratory of Genetic Engineering, Shanghai Institute of Infectious Disease and Biosecurity, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Yuchen Cuia State Key Laboratory of Genetic Engineering, Shanghai Institute of Infectious Disease and Biosecurity, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Yanjia Chena State Key Laboratory of Genetic Engineering, Shanghai Institute of Infectious Disease and Biosecurity, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Lulu Yanga State Key Laboratory of Genetic Engineering, Shanghai Institute of Infectious Disease and Biosecurity, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Jun Liuc State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China;d Fubio (Suzhou) Biomedical Technology Co., Ltd., Suzhou, People’s Republic of ChinaView further author information
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Huanzhang Zhuc State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Shibo Jiange Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, People’s Republic of ChinaView further author information
&
Pengfei Wanga State Key Laboratory of Genetic Engineering, Shanghai Institute of Infectious Disease and Biosecurity, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China;c State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2454-7652View further author information
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Pages 477-481 | Received 27 Dec 2021, Accepted 12 Jan 2022, Published online: 04 Feb 2022

Figures & data

Figure 1. Neutralization of pseudotyped WT (D614G) and Omicron (B.1.1.529) viruses by convalescent sera (a), sera collected at day 14 post 2-dose BBIBP-CorV (b), sera collected before vs. at day 14 post the booster dose (c), and sera collected at day 14 post-BBIBP-CorV or -ZF001 booster dose (d). For all panels, values above the symbols denote geometric mean titer and the numbers in parentheses denote the proportion of positive sera with ID50 above the LOQ (dotted lines, >1:50). P values were determined by using a Wilcoxon matched-pairs signed-rank test (two-tailed).

Figure 1. Neutralization of pseudotyped WT (D614G) and Omicron (B.1.1.529) viruses by convalescent sera (a), sera collected at day 14 post 2-dose BBIBP-CorV (b), sera collected before vs. at day 14 post the booster dose (c), and sera collected at day 14 post-BBIBP-CorV or -ZF001 booster dose (d). For all panels, values above the symbols denote geometric mean titer and the numbers in parentheses denote the proportion of positive sera with ID50 above the LOQ (dotted lines, >1:50). P values were determined by using a Wilcoxon matched-pairs signed-rank test (two-tailed).

Figure 2. Neutralization of pseudotyped WT (D614G) and Omicron (B.1.1.529) viruses by mAbs targeting different epitopes.

Figure 2. Neutralization of pseudotyped WT (D614G) and Omicron (B.1.1.529) viruses by mAbs targeting different epitopes.
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Data availability

Materials used in this study will be made available but may require execution of a materials transfer agreement. All the data are provided in the paper or the Supplementary Information.

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