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Emerging Microbes & Infections Volume 12, 2023 - Issue 2
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Influenza infections

Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses

Sasan Fereidounia Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Vienna, AustriaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3508-991XView further author information
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Elke Starickb Friedrich Loeffler Institute, Insel Riems, GermanyView further author information
,
Kobey Karamendinc Laboratory for Ecology of Viruses, Research and Production Center for Microbiology and Virology, Almaty, KazakhstanORCID Iconhttps://orcid.org/0000-0003-0829-3330View further author information
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Cecilia Di Genovad Universities of Kent & Greenwich, Chatham Maritime, Kent, UKORCID Iconhttps://orcid.org/0000-0002-2121-0715View further author information
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Simon D. Scottd Universities of Kent & Greenwich, Chatham Maritime, Kent, UKORCID Iconhttps://orcid.org/0000-0002-8290-0461View further author information
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Yelizaveta Khanc Laboratory for Ecology of Viruses, Research and Production Center for Microbiology and Virology, Almaty, KazakhstanORCID Iconhttps://orcid.org/0000-0002-6279-3419View further author information
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Timm Harderb Friedrich Loeffler Institute, Insel Riems, GermanyORCID Iconhttps://orcid.org/0000-0003-2387-378XView further author information
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Aidyn Kydyrmanovc Laboratory for Ecology of Viruses, Research and Production Center for Microbiology and Virology, Almaty, KazakhstanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8374-6128View further author information
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Article: 2225645 | Received 17 Jan 2023, Accepted 12 Jun 2023, Published online: 27 Jun 2023

Figures & data

Figure 1. The complete open reading frame (ORF) of the HA gene of A/ Common Pochard/Kazakhstan/Kz52/2008 influenza virus (new subtype), compared to closely related H9 subtype isolates. Representative isolates for each lineage included: H9-bat: A/Bat/Egypt/381OP/2017(H9N2), H9-Y280: A/Chicken/Beijing/1/97(H9N2), H9-G1: A/quail/Hong Kong/G1/97(H9N2), H9-Y439: A/Duck/Hong Kong/Y439/97(H9N2), H9-N. America: A/Mallard/California/D1713634/2017(H9N2), H9-Korea: A/chicken/Korea/GH2/2007(H9N2).

Figure 1. The complete open reading frame (ORF) of the HA gene of A/ Common Pochard/Kazakhstan/Kz52/2008 influenza virus (new subtype), compared to closely related H9 subtype isolates. Representative isolates for each lineage included: H9-bat: A/Bat/Egypt/381OP/2017(H9N2), H9-Y280: A/Chicken/Beijing/1/97(H9N2), H9-G1: A/quail/Hong Kong/G1/97(H9N2), H9-Y439: A/Duck/Hong Kong/Y439/97(H9N2), H9-N. America: A/Mallard/California/D1713634/2017(H9N2), H9-Korea: A/chicken/Korea/GH2/2007(H9N2).

Figure 3. Schematics showing predicted 3D models of the Kz52 HA Ribbon (right) and surface (left) formats generated using Phyre2 software. The images show the HA1 and HA2 subunits (green and yellow respectively), the cleavage site (red), and receptor-binding sites (blue).

Figure 3. Schematics showing predicted 3D models of the Kz52 HA Ribbon (right) and surface (left) formats generated using Phyre2 software. The images show the HA1 and HA2 subunits (green and yellow respectively), the cleavage site (red), and receptor-binding sites (blue).
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