Figures & data
Figure 1. Expression of the GLP-1 and GLP-2 mRNA of PGDPs+/+ and PGDPs−/− mice. Expressions of GLP-1 and GLP-2 are not observed in the PGDPs−/− mice.
Figure 2. (A) Villous height of the duodenum and three parts of the small intestine. No significant differences in villous height in each section are observed between the PGDPs−/− and PGDPS+/+ mice. A decrease in villous height is observed in both groups; the villous height of the small intestine is 34% of that in the duodenum in the PGDPs−/− mice and 40% in the PGDPS+/+ mice. (B) Crypt depth of the duodenum and three parts of the small intestine. No significant differences in crypt depth in each section are observed between the PGDPs−/− and PGDPS+/+ mice. Crypt depth shows no decline from the oral to anal side.
Each bar represents the mean height or depth and standard deviation.
Figure 3. (A) Time-dependent changes in disease activity index. The increases after the administration of dextran sodium for 5 days in the disease activity index until day 6 and the decline by day 12 are shown. Each point represents the mean ± SD of 7 PGDPs−/− and 7 PGDPS+/+ mice. (B) Time-dependent changes in BW. The decline in BW until day 9 and the recovery to 95% by day 20 are shown. Each point represents the mean ± SD of 7 PGDPs−/− and 7 PGDPS+/+ mice.
Figure 4. (A) Histological score of distal small intestine on colitis no significant differences were observed in histological score of distal small intestine between the PGDPs−/− and PGDPS+/+ mice. (B) Histological score of distal colon on colitis was not different on day 7 between the PGDPs−/− and PGDPS+/+ mice. On day 21, however, histological score of distal colon of PGDPs−/− was significantly higher than that of PGDPs−/−.
*p < 0.05.
