Laboratory correlation between vancomycin levels and serum creatinine in the nephrotoxicity of vancomycin

Figures & data

Figure 1. Division of the four groups in order to correlate the vancomycin (Vanco) and creatinine dosages (Cr), n = 127.

Table 1. Characteristics of the 127 patients using vancomycin

Age (years)	64.7 ± 13.0
Male	59.6%
Female	40.4%
Median Cr level at 1st dosage	2.38 ± 1.95 mg/dL
Median Vanco level at 1st dosage	22.9 ± 18.5 μg/mL
Deaths	21.6%

Table 2. Correlation between the patients clinical characteristics while on vancomycin and the laboratory correlation (n = 80)

		Group1		Group 2		Group 3		Group 4
		n	%	n	%	n	%	n	%
Age (years)	up to 49	1	5	3	15	3	16	4	19	0.033^*
	50–59	3	15	4	20	2	11	7	33
	60–69	11	55	5	25	7	37	0	0
	70–79	4	20	7	35	6	32	5	24
	>80	1	5	1	5	1	5	5	24
Gender	Female	9	45	3	15	12	63	8	38	0.021^*
	Male	11	55	17	85	7	37	13	62
HTN	No	7	39	2	13	3	16	7	35	0.176
	Yes	11	61	14	88	16	84	13	65
DM	No	10	56	11	69	10	53	16	84	0.159
	Yes	8	44	5	31	9	47	3	16
CCF	No	14	78	11	69	14	74	14	78	0.921
	Yes	4	22	5	31	5	26	4	22
Cirrhosis	No	15	83	13	81	16	84	17	94	0.679
	Yes	3	17	3	19	3	16	1	6
Neoplasia	No	12	67	12	75	12	63	11	61	0.839
	Yes	6	33	4	25	7	37	7	39
Sepsis	No	10	56	2	13	13	68	6	33	0.005^*
	Yes	8	44	14	88	6	32	12	67
Polymyxin	No	14	78	12	75	15	83	14	78	0.945
	Yes	4	22	4	25	3	17	4	22
Aminoglycoside	No	5	28	4	25	3	17	6	33	0.714
	Yes	13	72	12	75	15	83	12	67
AKI	No	4	22	0	0	11	58	10	56	0.001^*
	Yes	14	78	16	100	8	42	8	44
Death	No	10	50	6	30	11	58	11	52	0.317
	Yes	10	50	14	70	8	42	10	48

Notes: Group 1: Cr ≤ 1.4 + Vanco ≤ 20; Group 2: Cr ≤ 1.4 + Vanco > 20; Group3: Cr > 1.4 + Vanco ≤ 20; Group 4: Cr > 1.4 + Vanco > 20. HTN: hypertension; DM: diabetes mellitus; CCF: congestive heart failure; AKI: acute kidney lesion.

^* p < 0.05.

Table 3. Binary logistic regression of clinical factors associated with higher levels of creatinine (Cr) and vancomycin (Vanco), n = 80

Vanco > 20 + Cr > 1.4 Group 4	Sig.	Odds ratio adjusted	95% C.I. for EXP (B)
			Lower	Upper
AKI	0.041	3.17	1.05	9.56