Preparation and characterization of PCL-PEG-PCL polymersomes for delivery of clavulanic acid

Figures & data

Figure 1. H NMR spectrum of PCL-PEG-PCL tri-block copolymer in CDCl3.

Table 1. Molecular characterics of the synthesized copolymers

Copolymer	CL/EG feed	M n (Da)^a	M w (Da)^a	PdI^b	T m (°C)^c	DP PEG	DP^d PCL
PCL-PEG-PCL	2	13,343	8,310	1.6	44.01	136.36	73.09

^a Determined by GPC analysis using narrow molecular weight polystyrene standards.

^b M _w/M _n = Polydispersity index of the polymers (PdI) determined by GPC analysis.

^c Calculated from the first run of DSC as half of the extrapolated tangents.

^d DP: Degree of polymerization.

Figure 2. FTIR spectrum of PCL-PEG-PCL tri-block copolymer.

Figure 3. DSC thermogram of PCL-PEG-PCL copolymer.

Figure 4. GPC spectrum of PCL-PEG-PCL tri-block copolymer.

Figure 5. Particle size distribution and zeta potential of CLV/PCL-PEG-PCL nanoparticels (A) particle size distribution (B) zeta potential.

Figure 6. HPLC chromatogram of (A) CLV loaded polymersomes, (B) blank.

Figure 7. The release profiles of CLV from CLV-PCL-PEG-PCL polymersomes in different release media (A) pH 7.4, (B) pH 5.5.