Assessment of vitamin B₁₂ tissue stores in elderly proton pump inhibitor users

Figures & data

Table

Q1 Mass	Q3 Mass	Dwell (ms)	Analyte	DP	CE	CXP
117.0	72.9	40	MMA 1	−30	−13	−10
117.0	54.9	40	MMA 2	−30	−34	−10
120.0	75.9	40	MMA-d3	−30	−13	−10

Table 1. Characteristics of the PPI group and non-PPI group

	PPI group (n = 15)		Non-PPI group (n = 15)		Z score	p-value
	Mean ± SD	Median	Mean ± SD	Median
Anthropometrics
Age (years)	79.8 ± 8.4	77.0	80.3 ± 8.3	78.0	−0.81	0.416
BMI (kg/m2)	30.1 ± 3.7	29.3	27.4 ± 4.4	26.6	−2.78	0.005*
Body fat percent	37.9 ± 6.6	38.8	32.1 ± 9.2	31.9	−2.44	0.015*
Body fat mass (kg)	30.6 ± 8.0	28.0	23.5 ± 10.6	19.8	−2.67	0.008*
Lean body mass (kg)	49.9 ± 10.1	49.3	48.7 ± 13.3	43.3	−0.97	0.334
Diet/supplement intake
Average daily caloric intake (kcal/kg)	18.0 ± 3.2	17.9	19.6 ± 6.3	17.1	−0.94	0.347
Carbohydrate as % of caloric intake	49.3 ± 7.5	48.0	54.6 ± 9.1	56.0	−0.76	0.449
Protein as % of caloric intake	15.5 ± 2.0	16.0	16.5 ± 2.4	16.5	−0.71	0.477
Fat as % of caloric intake	35.2 ± 6.8	35.0	29.0 ± 8.0	30.0	−1.73	0.084
Dietary vitamin B12 (μg)	2.8 ± 2.1	2.3	3.4 ± 1.8	3.5	−1.57	0.117
Dietary vitamin B6 (mg)	1.0 ± 0.56	1.1	1.1 ± 0.46	1.1	−0.71	0.477
Dietary folate (μg)	280.0 ± 156.8	243.8	260.7 ± 150.2	209.5	−0.39	0.695
Supplemental vitamin B12 (μg)	17.7 ± 21.9	0.0	81.3 ± 255.8	0.0	−0.287	0.774
Supplemental vitamin B6 (mg)	4.7 ± 12.8	0.0	0.8 ± 1.6	0.0	−1.532	0.125
Supplemental folic acid (μg)	273.3 ± 293.9	400	120.0 ± 182.1	0.0	−1.562	0.118

Notes: Values are means ± SD. Total % carbohydrate, protein and fat may not equal 100% due to rounding. Only 13 pairs were available for analysis of dietary intake.

* p < 0.05 PPI group vs. non-PPI group.

Table 2. Observed uM-MA for PPI group and non-PPI group

	PPI group (n = 15)		Non-PPI group (n = 15)		Z score	p-value
	Mean ± SD	Median	Mean ± SD	Median
uM-MA levels (μg/mg creatinine)	1.1 ± 0.29	1.1	1.3 ± 0.91	1.1	−0.42	0.967

Note: Values are means ± SD.

Table 3. Observed uM-MA for PPI group and Non-PPI group by gender

Variable	PPI group				Non-PPI group
	Female (n = 12)		Male (n = 3)		Female (n = 12)		Male (n = 3)
	Mean ± SD	Median	Mean ± SD	Median	Mean ± SD	Median	Mean ± SD	Median
uM-MA (μg/mg creatinine)	1.06 ± 0.26	1.0	1.33 ± 0.35	1.3	1.31 ± 1.00	1.0	1.29 ± 0.48	1.2

Notes: Values are means ± standard deviation (M ± SD), Median (Mdn).