Survival analysis of Time to Death of Breast Cancer Patients: in case of Ayder Comprehensive Specialized Hospital Tigray, Ethiopia.

Figures & data

Figure 1. Schematic/diagrammatic/representation of joint model for breast cancer patients

Figure 2. Kaplan-Meier of pathology type

Figure 3. Kaplan-Meier of educational status

Table 1. Log rank test for categorical independent variables

Variable	Chisq	Df	P—Value
Metastatic	0.1	2	0.9
Educational Status	3.5	3	0.01
Marital Status	4	3	0.3
Treatment	7.2	2	0.03
Pathology Type	8.3	3	0.04
Stage	4.1	3	0.3
Residence	2.8	1	0.01

Table 2. Univariate analysis of Cox regression model for continuous variables

Variable	Df	P—Value	HR	95%CI for HR
Age	1	0.05	1.03	(0.99,1.067)
B_HGL	1	0.69	1.04	(0.823, 1.338)
B tumor size	1	0.04	1.045	(1.002,1.009)
B tumor cell	1	0.045	1.009	(1.0,1.02)

Table 3. Proportional hazard model assumption

Variables	rho	chisq	Sig
Age	−0.0346	8.92e-03	0.9247
Educational status
Primary	0.049	0.117	0.73
Secondary	0.299	2.57	0.109
Tertiary	0.257	1.47	0.225
Treatment
Surgery	-	-	-
Chemotherapy	0.355	0.075	0.86
Surgery $ chemotherapy	−0.032	0.043	0.83
Pathology type
LCIS	−0.102	0.238	0.626
DIC	−0.176	1.15	0.283
LIC	−0.251	3.6	0.06
Baseline tumor size	−0.0938	0.136	0.7125
Baseline tumor cell	0.095	20.27	0.6
Residence
Urban	0.0107	1.62e-01	0.6679
GLOBAL	NA	15.2	0.81

Table 4. Shows the Cox proportional hazards model for the selected variables

Variables	AHR	95%CI	Sig
Age	1.06	(1.005,1.13)	0.032
Educational stat
Illiterate	-		-
Primary	0.043	(0.00041,0.443)	0.008
Secondary	0.033	(0.0012,0.9)	0.043
Tertiary	0.013	(0.00046,0.371)	0.011
Pathology type
DCIS	-		-
LCIS	7.96	(0.245,25.76)	0.24
DIC	3.188	(0.98, 7.8)	0.06
LIC	6.925	(1.82, 8.5)	0.02
Residence
Rural	-		-
Urban	0.213	(0.05,0.92)	0.038
B tumor size	1.172	(1.06,1.29)	0.041
B tumor cell	1.005	(0.995,1.016)	0.294
Treatment
Surgery	-	-	-
Chemotherapy	0.0038	(0.00045,12.2)	0.61
Surgery $ chemotherapy	0.132	(0.01577,1.16)	0.062
AIC	178.05

Availability of data and materials

The datasets analyzed during the current study were available from the corresponding

author on reasonable request.