http://orcid.org/0000-0001-7147-3946
Figures & data
Figure 1. Role for endothelial progenitor reprogramming by Hedgehog in rhabdomyosarcoma oncogenesis. A) Model of endothelial cell and skeletal muscle development from Kinase insert domain receptor positive (KDR+) progenitors in the pharyngeal mesoderm on a Waddington epigenetic landscape. B) Proposed model of fusion-negative rhabdomyosarcoma tumorigenesis. Constitutive activation of Hedgehog signaling (Shh) by expression of constitutively active oncogenic SMOOTHENED (SmoM2) in aP2-Cre expressing endothelial progenitor cells results in their embryonic expansion, reprogramming and myogenic transdifferentiation into fusion-negative rhabdomyosarcoma. Immunostaining for Tomato (Red), Myosin Heavy Chain (Green) and DAPI (Blue). Abbreviations in figure as follows: adipose protein 2 (aP2), T-box 1 (TBX1), Paired-like homeodomain transcription factor 2 (PITX2), Transcription factor 21 (TCF21), rhabdomyosarcoma (RMS). Adapted from.Citation9
