Figure 1. ABL kinase regulation of cathepsin secretion in melanoma. ABL1/ABL2 are activated by receptor tyrosine kinases (RTKs), SRC Family Kinases (SFK) and BRAF-ERK, and subsequently induce SP1, ETS1, and RELA expression/nuclear translocation, and binding to cathepsin promoters. These events induce cathepsin transcription, secretion, invasion, and metastasis. PM: Plasma Membrane; ER: Endoplasmic Reticulum; and ECM: Extracellular Matrix.
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