Clinical use of anti-histone antibodies in idiopathic and drug-induced lupus

Figures & data

Figure 1. Basic subunit of DNA. A nucleosome comprises a histone octamer core with DNA wrapped around, resembling ‘beads on a string’.

Table 1. Prevalence of IgG antibodies to total histones and histone subunits in selected disorders.

Histone component	Disease	Average prevalence, % (range)	References
Total histone	Rheumatoid arthritis	5	[50]
	Various malignancies		[50]
	Inflammatory myositides	17	[20]
	Systemic sclerosis	30 (29–33)	[41,48]
	Schizophrenia	23	[51]
	Systemic lupus erythematosus (SLE)	53 (24–81)	[24,39,43,50,52,53]
	Drug-induced lupus erythematosus (DILE)	96	[36]
H1	Human immunodeficiency virus		[54]
	Inflammatory myositides	17	[20]
	Mixed connective tissue disease (MCTD)		[55]
	SLE	32 (6–49)	[36,39,42,53]
	DILE	9	[36]
H2A	SLE	34	[53]
	DILE	67	[35]
	Systemic sclerosis		[56]
	MCTD		[55]
H2B	SLE	63	[53]
	Systemic sclerosis		[56]
	MCTD		[55]
H2A-H2B complex	SLE	9	[26]
	DILE	91	[36]
H2A-H2B-DNA complex	SLE	10	[26]
	DILE	30	[57]
H3	SLE	42 (37–56)	[42,53]
	DILE	13 (H3–H4 complex)	[36]
H4	SLE	1 (1–22)	[39,53]

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