Figures & data
Figure 1. Roles of iron metabolism in the molecular mechanisms and signaling pathways of ferroptosis.
Figure 2. Core regulators of the molecular mechanisms and signaling pathways of ferroptosis.
Figure 3. Role of autophagy in ferroptosis. (A) NCOA4-mediated ferritinophagy promotes iron accumulation. (B) RAB7A-mediated lipophagy promotes lipid peroxidation. (C) BECN1-mediated system Xc- inhibition promotes GSH depletion and ferroptosis. (D) STAT3-mediated CTSB expression and release announce lysosomal cell death. (E) HSP90-mediated LAMP2A stability contributes to CMA-mediated GPX4 degradation.
Data availability statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.