The role of ferroptosis in the side effects of dexamethasone

References

• Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R. 2017. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. 551(7682):639–643.
   PubMed Web of Science ®Google Scholar
• Arbiser JL, Bonner MY, Ward N, Elsey J, Rao S. 2018. Selenium unmasks protective iron armor: a possible defense against cutaneous inflammation and cancer. Biochim Biophys Acta Gen Subj. 1862(11):2518–2527.
   PubMed Web of Science ®Google Scholar
• Bai Y, Meng L, Han L, Jia Y, Zhao Y, Gao H, Kang R, Wang X, Tang D, Dai E. 2019. Lipid storage and lipophagy regulates ferroptosis. Biochem Biophys Res Commun. 508(4):997–1003.
   PubMed Web of Science ®Google Scholar
• Bridges RJ, Natale NR, Patel SA. 2012. System xc(-) cystine/ glutamate antiporter: an update on molecular pharmacology and roles within the CNS. Br J Pharmacol. 165(1):20–34.
   PubMed Web of Science ®Google Scholar
• De Domenico I, Vaughn MB, Li L, Bagley D, Musci G, Ward DM, Kaplan J. 2006. Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome. Embo J. 25(22):5396–5404.
   PubMed Web of Science ®Google Scholar
• Deng J, Guo Y, Yuan F, Chen S, Yin H, Jiang X, Jiao F, Wang F, Ji H, Hu G, et al. 2020. Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening. Autophagy. 16(3):451–465.
   PubMed Web of Science ®Google Scholar
• Détivaud L, Island ML, Jouanolle AM, Ropert M, Bardou-Jacquet E, Le Lan C, Mosser A, Leroyer P, Deugnier Y, David V, et al. 2013. Ferroportin diseases: functional studies, a link between genetic and clinical phenotype. Hum Mutat. 34(11):1529–1536.
   PubMed Web of Science ®Google Scholar
• Ding J, Li F, Cong Y, Miao J, Wu D, Liu B, Wang L. 2019. Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice. Life Sci. 235:116800.
   PubMed Web of Science ®Google Scholar
• Distéfano AM, Martin MV, Córdoba JP, Bellido AM, D'Ippólito S, Colman SL, Soto D, Roldán JA, Bartoli CG, Zabaleta EJ, et al. 2017. Heat stress induces ferroptosis-like cell death in plants. J Cell Biol. 216(2):463–476.
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al. 2012. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 149(5):1060–1072.
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS, et al. 2014. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 3:e02523.
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M, Superti-Furga G, Stockwell BR. 2015. Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chem Biol. 10(7):1604–1609.
   PubMed Web of Science ®Google Scholar
• Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, et al. 2017. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 13(1):91–98.
   PubMed Web of Science ®Google Scholar
• Feng M, Zhang R, Yang P, Wang K, Qiang H. 2019. Interaction between necroptosis and apoptosis in MC3T3-E1 cell death induced by dexamethasone. J South Med Univ. 39(9):1030–1037.
   Google Scholar
• Folco G, Murphy RC. 2006. Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol Rev. 58(3):375–388.
   PubMed Web of Science ®Google Scholar
• Forcina GC, Dixon SJ. 2019. Gpx4 at the crossroads of lipid homeostasis and ferroptosis. Proteomics. 19(18):e1800311.
   PubMed Web of Science ®Google Scholar
• Gao H, Bai Y, Jia Y, Zhao Y, Kang R, Tang D, Dai E. 2018. Ferroptosis is a lysosomal cell death process. Biochem Biophys Res Commun. 503(3):1550–1556.
   PubMed Web of Science ®Google Scholar
• Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. 2016. Ferroptosis is an autophagic cell death process. Cell Res. 26(9):1021–1032.
   PubMed Web of Science ®Google Scholar
• Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J. 2000. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 1(6):489–495.
   PubMed Web of Science ®Google Scholar
• Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ, 3rd, Kang R, Tang D, 2016. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 12(8):1425–1428.
   PubMed Web of Science ®Google Scholar
• Imoto S, Kono M, Suzuki T, Shibuya Y, Sawamura T, Mizokoshi Y, Sawada H, Ohbuchi A, Saigo K. 2018. Haemin-induced cell death in human monocytic cells is consistent with ferroptosis. Transfus Apher Sci. 57(4):524–531.
   PubMed Web of Science ®Google Scholar
• Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, et al. 2018. Selenium utilization by GPX4 Is required to prevent hydroperoxide-induced ferroptosis. Cell. 172(3):409–422.
   PubMed Web of Science ®Google Scholar
• Jacobsen AV, Lowes KN, Tanzer MC, Lucet IS, Hildebrand JM, Petrie EJ, van Delft MF, Liu Z, Conos SA, Zhang JG, et al. 2016. HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. Cell Death Dis. 7(1):e2051.
   PubMedGoogle Scholar
• Jiang L, Kon N, Li T, Wang S-J, Su T, Hibshoosh H, Baer R, Gu W. 2015. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 520(7545):57–62.
   PubMed Web of Science ®Google Scholar
• Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, et al. 2017. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 13(1):81–90.
   PubMed Web of Science ®Google Scholar
• Kang R, Zeh HJ, Lotze MT, Tang D. 2011. The beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18(4):571–580.
   PubMed Web of Science ®Google Scholar
• Khan AA, Rodriguez A, Kaakinen M, Pouta A, Hartikainen AL, Jarvelin MR. 2011. Does in utero exposure to synthetic glucocorticoids influence birthweight, head circumference and birth length? A systematic review of current evidence in humans. Paediatr Perinat Epidemiol. 25(1):20–36.
   PubMed Web of Science ®Google Scholar
• Kim EH, Wong SW, Martinez J. 2019. Programmed necrosis and disease: we interrupt your regular programming to bring you necroinflammation. Cell Death Differ. 26(1):25–40.
   PubMed Web of Science ®Google Scholar
• Knutson MD. 2019. Non-transferrin-bound iron transporters. Free Radic Biol Med. 133:101–111.
   PubMed Web of Science ®Google Scholar
• Koppenol WH. 2001. The haber-weiss cycle–70 years later. Redox Rep. 6(4):229–234.
   PubMed Web of Science ®Google Scholar
• Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D, Vandenabeele P, Zhivotovsky B, Blagosklonny MV, Malorni W, Knight, et al. 2005. Classification of cell death: recommendations of the nomenclature committee on cell death. Cell Death Differ. 12(Suppl 2):1463–1467.
   PubMedGoogle Scholar
• Kroemer G, Jäättelä M. 2005. Lysosomes and autophagy in cell death control. Nat Rev Cancer. 5(11):886–897.
   PubMed Web of Science ®Google Scholar
• Kuhn H, Banthiya S, van Leyen K. 2015. Mammalian lipoxygenases and their biological relevance. Biochim Biophys Acta. 1851(4):308–330.
   PubMed Web of Science ®Google Scholar
• Lai CS, Piette LH. 1978. Spin-trapping studies of hydroxyl radical production involved in lipid peroxidation. Arch Biochem Biophys. 190(1):27–38.
   PubMed Web of Science ®Google Scholar
• Lee YS, Kalimuthu K, Seok Park Y, Makala H, Watkins SC, Choudry MHA, Bartlett DL, Tae Kwon Y, Lee YJ. 2020. Ferroptotic agent-induced endoplasmic reticulum stress response plays a pivotal role in the autophagic process outcome. J Cell Physiol. 235(10):6767–6778.
   PubMed Web of Science ®Google Scholar
• Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, et al. 2013. The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal. 18(5):522–555.
   PubMed Web of Science ®Google Scholar
• Li D, Xu T, Cao Y, Wang H, Li L, Chen S, Wang X, Shen Z. 2015. A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc Natl Acad Sci U S A. 112(16):5017–5022.
   PubMed Web of Science ®Google Scholar
• Li GF, Pan YZ, Sirois P, Li K, Xu YJ. 2012. Iron homeostasis in osteoporosis and its clinical implications. Osteoporos Int. 23(10):2403–2408.
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B, Wang G. 2020. Ferroptosis: past, present and future. Cell Death Dis. 11(2):88.
   PubMed Web of Science ®Google Scholar
• Liu K, Czaja MJ. 2013. Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ. 20(1):3–11.
   PubMed Web of Science ®Google Scholar
• Lőrincz T, Jemnitz K, Kardon T, Mandl J, Szarka A. 2015. Ferroptosis is involved in Acetaminophen induced cell death. Pathol Oncol Res. 21(4):1115–1121.
   PubMed Web of Science ®Google Scholar
• Lu J, Yang J, Zheng Y, Chen X, Fang S. 2019. Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence. Sci Rep. 9(1):16130.
   PubMedGoogle Scholar
• Ma S, Henson ES, Chen Y, Gibson SB. 2016. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 7(7):e2307.
   PubMed Web of Science ®Google Scholar
• Maiorino M, Conrad M, Ursini F. 2018. Gpx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues. Antioxid Redox Signaling. 29(1):61–74.
   PubMed Web of Science ®Google Scholar
• Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. 2014. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 509(7498):105–109.
   PubMed Web of Science ®Google Scholar
• Nandal A, Ruiz JC, Subramanian P, Ghimire-Rijal S, Sinnamon RA, Stemmler TL, Bruick RK, Philpott CC. 2011. Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2. Cell Metab. 14(5):647–657.
   PubMed Web of Science ®Google Scholar
• Philpott CC, Jadhav S. 2019. The ins and outs of iron: escorting iron through the mammalian cytosol. Free Radic Biol Med. 133:112–117.
   PubMed Web of Science ®Google Scholar
• Protchenko O, Baratz E, Jadhav S, Li F, Shakoury-Elizeh M, Gavrilova O, Ghosh MC, Cox JE, Maschek JA, Tyurin VA, et al. 2021. Iron chaperone poly rC binding protein 1 protects mouse liver from lipid peroxidation and steatosis. Hepatology. 73(3):1176–1193.
   PubMed Web of Science ®Google Scholar
• Ramamoorthy S, Cidlowski JA. 2013. Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance. Endocr Dev. 24:41–56.
   PubMedGoogle Scholar
• Revollo JR, Cidlowski JA. 2009. Mechanisms generating diversity in glucocorticoid receptor signaling. Ann N Y Acad Sci. 1179:167–178.
   PubMed Web of Science ®Google Scholar
• Roberts D, Dalziel S. 2006. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 3:Cd004454.
   PubMed Web of Science ®Google Scholar
• Sato H, Tamba M, Ishii T, Bannai S. 1999. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J Biol Chem. 274(17):11455–11458.
   PubMed Web of Science ®Google Scholar
• Schakman O, Kalista S, Barbé C, Loumaye A, Thissen JP. 2013. Glucocorticoid-induced skeletal muscle atrophy. Int J Biochem Cell Biol. 45(10):2163–2172.
   PubMed Web of Science ®Google Scholar
• Schroeder B, Schulze RJ, Weller SG, Sletten AC, Casey CA, McNiven MA. 2015. The small GTPase Rab7 as a central regulator of hepatocellular lipophagy. Hepatology. 61(6):1896–1907.
   PubMed Web of Science ®Google Scholar
• Shi J, Gao W, Shao F. 2017. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 42(4):245–254.
   PubMed Web of Science ®Google Scholar
• Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, et al. 2018. AMPK-Mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system X activity. Curr Biol. 28(15):2388–2399.
   PubMed Web of Science ®Google Scholar
• Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, Tang D. 2016. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 63(1):173–184.
   PubMed Web of Science ®Google Scholar
• Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X, Wang H, Cao L, Tang D. 2015. HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene. 34(45):5617–5625.
   PubMed Web of Science ®Google Scholar
• Sun Y, Chen P, Zhai B, Zhang M, Xiang Y, Fang J, Xu S, Gao Y, Chen X, Sui X, et al. 2020. The emerging role of ferroptosis in inflammation. Biomed Pharmacother. 127:110108.
   PubMed Web of Science ®Google Scholar
• Torii S, Shintoku R, Kubota C, Yaegashi M, Torii R, Sasaki M, Suzuki T, Mori M, Yoshimoto Y, Takeuchi T, et al. 2016. An essential role for functional lysosomes in ferroptosis of cancer cells. Biochem J. 473(6):769–777.
   PubMedGoogle Scholar
• Wang L, Jiao XF, Wu C, Li XQ, Sun HX, Shen XY, Zhang KZ, Zhao C, Liu L, Wang M, et al. 2021. Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis. Cell Death Discov. 7(1):251.
   PubMed Web of Science ®Google Scholar
• Wang T, Fu X, Chen Q, Patra JK, Wang D, Wang Z, Gai Z. 2019. Arachidonic acid metabolism and kidney inflammation. Int J Mol Sci. 20(15):3683.
   PubMed Web of Science ®Google Scholar
• Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, et al. 2016. The protective role of mitochondrial ferritin on erastin-induced ferroptosis. Front Aging Neurosci. 8:308.
   PubMed Web of Science ®Google Scholar
• Weïwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber, et al. 2012. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 22(4):1822–1826.
   PubMed Web of Science ®Google Scholar
• Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J. 2019. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proc Natl Acad Sci U S A. 116(8):2996–3005.
   PubMed Web of Science ®Google Scholar
• Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D. 2016. Ferroptosis: process and function. Cell Death Differ. 23(3):369–379.
   PubMed Web of Science ®Google Scholar
• Xue Y, Enosi Tuipulotu D, Tan WH, Kay C, Man SM. 2019. Emerging activators and regulators of inflammasomes and pyroptosis. Trends Immunol. 40(11):1035–1052.
   PubMed Web of Science ®Google Scholar
• Yang RZ, Xu WN, Zheng HL, Zheng XF, Li B, Jiang LS, Jiang SD. 2021. Exosomes derived from vascular endothelial cells antagonize glucocorticoid-induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts. J Cell Physiol. 236(9):6691–6705.
   PubMed Web of Science ®Google Scholar
• Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR. 2016. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci USA. 113(34):E4966–E4E75.
   PubMed Web of Science ®Google Scholar
• Yang WS, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell BR. 2012. Identification of simple compounds with microtubule-binding activity that inhibit cancer cell growth with high potency. ACS Med Chem Lett. 3(1):35–38.
   PubMed Web of Science ®Google Scholar
• Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, et al. 2014. Regulation of ferroptotic cancer cell death by GPX4. Cell. 156(1–2):317–331.
   PubMed Web of Science ®Google Scholar
• Zhao XM, Chen Z, Zhao JB, Zhang PP, Pu YF, Jiang SH, Hou JJ, Cui YM, Jia XL, Zhang SQ. 2016. Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis. Cell Death Dis. 7(2):e2089.
   PubMedGoogle Scholar
• Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL. 2020. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nat Chem Biol. 16(3):302–309.
   PubMed Web of Science ®Google Scholar