Effect of Nitric Oxide Synthase Inhibition and Saline Administration on Blood Pressure and Renal Sodium Handling During Experimental Sepsis in Rats

Figures & data

Figure 1. Effect of oral administration of L-NAME or subcutaneous isotonic fluid reposition in sham-operated L-NAME-treated (Sh + L-NAME), the cecal ligation and puncture L-NAME-treated (CLP + L-NAME) and CLP 0.15 M NaCl-treated (NaCl) rats on creatinine clearance (C_Cr), fractional excretion of sodium (FE_Na), proximal (FEP_Na) and post-proximal (FEPP_Na) fractional excretion of sodium, fractional excretion of potassium (FE_K), and blood pressure compared to sham-operated (Sh) and CLP rats (CLP) untreated rats. The data were calculated as the area under curve vs. time (AUC, Δ% min⁻¹) and reported as the means ± SEM. *p ≤ 0.05 vs. GI group (ANOVA and Bonferroni's contrast test).

Table 1. Effect of oral administration of L-NAME or subcutaneous isotonic fluid reposition in sham-operated L-NAME-treated (GII), the cecal ligation and puncture (CLP) L-NAME-treated (GIV), and CLP 0.15 M NaCl-treated (GV) rats on body weight, serum pH, P_aCO₂, , sodium, potassium, and lithium levels compared to sham-operated (GI) and CLP rats (GIII) untreated rats. The data are reported as the means ± SEM for 10 rats per group

	Body weight		PaCO2		Na^+	K^+	Li^+
Groups	(g)	pH	(mmHg)	(mM)	(mM)	(mM)	(µM)
GI	300 ± 15	7.46 ± 0.05	42.9 ± 0.9	23.0 ± 2.3	143 ± 0.9	3.7 ± 0.1	107 ± 5.0
GII	289 ± 16	7.01 ± 0.05a	21.8 ± 0.5a	7.0 ± 2.5a	142 ± 1.2	4.5 ± 0.1	117 ± 6.0
GIII	291 ± 19	7.37 ± 0.05	40.7 ± 0.7	22.9 ± 3.0	143 ± 0.4	4.4 ± 0.1	09 ± 8.0
GIV	302 ± 14	6.95 ± 006a	17.8 ± 0.9a	9.5 ± 2.4a	145 ± 0.7	4.3 ± 0.2	110 ± 7.2
GV	298 ± 11	7.00 ± 0.06a	20.1 ± 1.3a	10.1 ± 2.6a	144 ± 1.2	4.3 ± 0.5	109 ± 8.6

^ap ≤ 0.05 vs. GI group (ANOVA and Bonferroni’ s contrast test).