Intravenous Treatment of Hyperhomocysteinemia in Patients on Chronic Hemodialysis—A Pilot Study

Figures & data

Figure 1. Homocysteine levels during period 1. Data are given as box plots. The box indicates median and 25^th to 75^th percentile, the whiskers minimum and maximum. Significant differences versus baseline are indicated by asterisks (^*).

Table 1. Demographic Characteristics of the Cohort

	Number (n)	Age (years)	Homocysteine (µmol/l)	Folic acid (ng/ml)	Vitamin B12 (pg/ml)
All	13	63.7 ± 16.9	30.5 ± 76	9.6 ± 4.6	382 ± 133
Women	6	61.7 ± 21.7	28.5 ± 8.1	7.5 ± 4.0	342 ± 122
Men	7	65.4 ± 10.9	32.2 ± 6.7	11 ± 4.4	416 ± 133

Data are given as mean ± SD.

Table 2. Survey of the Effects of Intravenous Treatment of Hyperhomocysteinemia in ESRD

Author	Medication	Dosage [mg]	p.o./IV	Intervals	Duration	tHcy reduction rate
Touam et al.[15]	Folinic acid	50	IV	Weekly	7,5–17 months	67%
	Vitamin B6	250	IV	3 × /week
Trembley et al. 2000[23]	Folic acid	10	IV	3 × /week	12 months	35%
Buccianti et al. 2001[24]	Folinic acid	0.9	IV	3 × /week	6 months	40%
	Cyanocobalamin	0.5	IV	3 × /week
	Hydroxycobalamin	1.5	IV	3 × /week
Corghi et al. 2002[25]	Folinic acid	0.9	IV	3 × /week	6 months	38%
	Vitamin B12	1500	IV	3 × /week
Ducloux et al.[13]	Vitamin B12	3000	p.o.	Weekly	6 months	46%
	Vitamin B6	750	IV	Weekly
	Calcium‐folinat	50	IV	Weekly
Trimarchi et al.[20]	Vitamin B12	0.5	IV	2 × /week	4 months	44%
	Folic acid	10	p.o.	Daily
Kaplan et al.[12]	Vitamin B12	1	IV	Monthly	3 months	11%
Sombolos et al.[10]	Folic acid	5	p.o.	3 × /week	3 months	30%
	Vitamin B1	250	IV	3 × /week
	Vitamin B6	250	IV	3 × /week
	Vitamin B12	1500	IV	3 × /week
Koyoma et al. 2002[14]	Folic acid	15	p.o.	Daily	3 weeks	57%
	Methylcobalamin	500	IV	3 × /week
Koyoma et al. 2002	Vitamin B6	60	p.o.	Daily	3 weeks	60%
	Folic acid	15	p.o.	Daily
	Methylcobalamin	500	IV	3 × /week

IV = Intravenously, p.o. = orally.

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