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Molecular and Cellular Biology Volume 36, 2016 - Issue 12
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Minireview

Cross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic Implications

Ion Cristóbala Translational Oncology Division, Oncohealth Institute, IIS Fundación Jiménez Diaz, UAM, University Hospital Fundación Jiménez Diaz, Madrid, SpainCorrespondence[email protected] [email protected]
,
Federico Rojob Pathology Department, IIS Fundación Jiménez Diaz, UAM, Madrid, Spain
,
Juan Madoz-Gúrpideb Pathology Department, IIS Fundación Jiménez Diaz, UAM, Madrid, Spain
&
Jesús García-Foncillasa Translational Oncology Division, Oncohealth Institute, IIS Fundación Jiménez Diaz, UAM, University Hospital Fundación Jiménez Diaz, Madrid, SpainCorrespondence[email protected] [email protected]
Pages 1734-1739 | Published online: 17 Mar 2023
 
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Abstract

Aberrant activation of the Wnt/β-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This minireview analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signaling regulators and the pivotal role of the tumor suppressor protein phosphatase 2A (PP2A) modulating these pathways.

Supplemental material for this article may be found at http://dx.doi.org/10.1128/MCB.00130-16.

ACKNOWLEDGMENTS

This work was supported by grants PI13/02609 and PI15/00934 from the Instituto de Salud Carlos III FEDER.

We declare that we have no conflict of interest.

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