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Hematology Volume 16, 2011 - Issue 5
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Original Article

Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells

Cigir Biray AvciDepartment of Medical BiologySchool of Medicine, Ege University, Izmir, Turkey
,
Sunde YilmazDepartment of Medical BiologySchool of Medicine, Ege University, Izmir, Turkey
,
Zeynep Ozlem DoganDepartment of Medical BiologySchool of Medicine, Ege University, Izmir, Turkey
,
Güray SaydamDepartment of HematologySchool of Medicine, Ege University, IzmirTurkey
,
Yavuz DodurgaSchool of MedicineDepartment of Medical Biology, School of Medicine, Pamukkale University, Denizli, Turkey
,
Huseyin Atakan EkizDepartment of Molecular Biology and Genetics Faculty of Science, Izmir Institute of Technology, Turkey
,
Melis KartalDepartment of Molecular Biology and Genetics Faculty of Science, Izmir Institute of Technology, Turkey
,
Fahri SahinDepartment of HematologySchool of Medicine, Ege University, IzmirTurkey
,
Yusuf BaranDepartment of Molecular Biology and Genetics Faculty of Science, Izmir Institute of Technology, TurkeyCorrespondence[email protected]
&
Cumhur GunduzDepartment of Medical BiologySchool of Medicine, Ege University, Izmir, Turkey
 show all
Pages 303-307 | Published online: 12 Nov 2013

Figures & data

Figure 1. Effects of quercetin on cell viability of leukemia cells. Cytotoxic effects of Quercetin on CCRF-CEM (A), HL60 (B), and K562 (C) cells were examined by trypan blue dye exclusion assay for 48 and 72 hours.

Figure 1. Effects of quercetin on cell viability of leukemia cells. Cytotoxic effects of Quercetin on CCRF-CEM (A), HL60 (B), and K562 (C) cells were examined by trypan blue dye exclusion assay for 48 and 72 hours.

Figure 2. Apoptotic and necrotic effects of quercetin on CCRF-CEM (A), HL60 (B), and K562 (C) cells were examined by using acridine orange/ethidium bromide staining for 48 and 72 hours.

Figure 2. Apoptotic and necrotic effects of quercetin on CCRF-CEM (A), HL60 (B), and K562 (C) cells were examined by using acridine orange/ethidium bromide staining for 48 and 72 hours.

Figure 3. Effects of quercetin on hTERT mRNA levels. Expression levels of hTERT were determined by qPCR in CCRF-CEM (A), HL60 (B), and K562 (C) cells treated with increasing concentrations of quercetin for 48 and 72 hours.

Figure 3. Effects of quercetin on hTERT mRNA levels. Expression levels of hTERT were determined by qPCR in CCRF-CEM (A), HL60 (B), and K562 (C) cells treated with increasing concentrations of quercetin for 48 and 72 hours.

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