Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells

References

• Harborne JB. Nature, distribution and function of plant flavonoids. Prog Clin Biol Res 1986;213:15–24.
   PubMedGoogle Scholar
• Salvador MJ, Pereira PS, França SC, Candido RC, Ito IY, Dias DA. Bioactive chemical constituents and comparative antimicrobial activity of callus culture and adult plant extracts from Alternanthera tenella. Z Naturforsch C 2009;64:373–81.
   PubMed Web of Science ®Google Scholar
• Li J, Ou-Lee TM, Raba R, Amundson RG, Last RL. Arabidopsis flavonoid mutants are hypersensitive to UV-B irradiation. Plant Cell 1993;5:171–9.
   PubMed Web of Science ®Google Scholar
• Brown DE, Rashotte AM, Murphy AS, Normanly J, Tague BW, Peer WA, et al.. Flavonoids act as negative regulators of auxin transport in vivo in arabidopsis. Plant Physiol 2001;126:524–35.
   PubMed Web of Science ®Google Scholar
• Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 1996;20:933–56.
   PubMed Web of Science ®Google Scholar
• Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, et al.. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 1995;155:381–6.
   PubMed Web of Science ®Google Scholar
• Ferrandiz ML, Alcaraz MJ. Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. Agents Actions 1991;32:283–8.
   PubMedGoogle Scholar
• Osman HE, Maalej N, Shanmuganayagam D, Folts JD. Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys. J Nutr 1998;128:2307–12.
   PubMed Web of Science ®Google Scholar
• Wang HK, Xia Y, Yang ZY, Natschke SL, Lee KH. Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents. Adv Exp Med Biol 1998;439:191–225.
   PubMed Web of Science ®Google Scholar
• Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 2002;22:19–34.
   PubMed Web of Science ®Google Scholar
• Ferrali M, Signorini C, Caciotti B, Sugherini L, Ciccoli L, Giachetti D, et al.. Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity. FEBS Lett 1997;416:123–9.
   PubMed Web of Science ®Google Scholar
• Hertog MG, Feskens EJ, Kromhout D. Antioxidant flavonols and coronary heart disease risk. Lancet 1997;349:699.
   PubMed Web of Science ®Google Scholar
• Hirvonen T, Virtamo J, Korhonen P, Albanes D, Pietinen P. Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes Control 2001;12:789–96.
   PubMed Web of Science ®Google Scholar
• Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, et al.. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002;76:560–8.
   PubMed Web of Science ®Google Scholar
• Tabak C, Arts IC, Smit HA, Heederik D, Kromhout D. Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study. Am J Respir Crit Care Med 2001;164:61–4.
   PubMed Web of Science ®Google Scholar
• Manjeet KR, Ghosh B. Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages. Int J Immunopharmacol 1999;21:435–43.
   PubMed Web of Science ®Google Scholar
• Geraets L, Moonen HJ, Brauers K, Wouters EF, Bast A, Hageman GJ. Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells. J Nutr 2007;137:2190–5.
   PubMed Web of Science ®Google Scholar
• Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, et al.. Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer 2000;87:595–600.
   PubMed Web of Science ®Google Scholar
• Chen Y, Li XX, Xing NZ, Cao XG. Quercetin inhibits choroidal and retinal angiogenesis in vitro. Graefes Arch Clin Exp Ophthalmol 2008;246:373–8.
   PubMed Web of Science ®Google Scholar
• Tough IM, Court Brown WM, Baikie AG, Buckton KE, Harnden DG, Jacobs PA, et al.. Cytogenetic studies in chronic myeloid leukaemia and acute leukaemia associated with monogolism. Lancet 1961;1:411–7.
   PubMed Web of Science ®Google Scholar
• Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood 2000;96:3343–56.
   PubMed Web of Science ®Google Scholar
• Kakizuka A, Miller WH, Umesono K, Warrell RP, Frankel SR, Murty VV, et al.. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell 1991;66:663–74.
   PubMed Web of Science ®Google Scholar
• Roman-Gomez J, Cordeu L, Agirre X, Jiménez-Velasco A, San José-Eneriz E, Garate L, et al.. Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia. Blood 2007;109:3462–9.
   PubMed Web of Science ®Google Scholar
• Omura-Minamisawa M, Diccianni MB, Batova A, Chang RC, Bridgeman LJ, Yu J, et al.. Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia. Clin Cancer Res 2000;6:1219–28.
   PubMed Web of Science ®Google Scholar
• Roman-Gomez J, Castillejo JA, Jimenez A, Gonzalez MG, Moreno F, Rodriguez Mdel C, et al.. 5′ CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia. Blood 2002;99:2291–6.
   PubMed Web of Science ®Google Scholar
• Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, et al.. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci USA 2007;104:19971–6.
   PubMed Web of Science ®Google Scholar
• Hoelzer D, Gokbuget N, Ottmann O, Pui CH, Relling MV, Appelbaum FR, et al.. Acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program 2002;2002:162–92.
   Google Scholar
• Kurz DJ, Decary S, Hong Y, Trivier E, Akhmedov A, Erusalimsky JD. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 2004;117:2417–26.
   PubMed Web of Science ®Google Scholar
• Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614–36.
   PubMed Web of Science ®Google Scholar
• Blackburn EH. Telomerases. Annu Rev Biochem 1992;61:113–29.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57–70.
   PubMed Web of Science ®Google Scholar
• Meyerson M. Role of telomerase in normal and cancer cells. J Clin Oncol 2000;18:2626–34.
   PubMed Web of Science ®Google Scholar
• Piskin O, Ozcan MA, Ozcan HG, Ates H, Demirkan F, Alacacioglu I, et al.. Synergistic effect of imatinib mesylate and fludarabine combination on Philadelphia chromosome-positive chronic myeloid leukemia cell lines. Turk J Hemat 2007;24:23–7.
   PubMedGoogle Scholar
• Knekt P, Järvinen R, Seppänen R, Hellövaara M, Teppo L, Pukkala E, et al.. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997;146:223–30.
   PubMed Web of Science ®Google Scholar