Serum bilirubin and lipoprotein-a: How are these associated with whole blood viscosity?

Figures & data

Figure 1. Hypothetical association between bilirubinaemia, haemoglobin, Lp(a), and blood viscosity – callouts indicating known points of association in the pathophysiology.

Table 1. Data description for LFTs and FBC

			Liver function tests					Full blood count
	Lp(a)	WBV	TP	BILI	ALP	ALT	AST	HGB	HCT	MCV	MCH	MCHC	RDW	PLT	WBCC	RBC
Mean	525	17.40	73	11	85	31	22	147	0.44	88.98	29.75	334	13.36	244	6.84	4.95
SD	596	0.97	4	5	33	28	10	13	0.04	5.63	2.02	12	1.00	66	1.78	0.49
Median	223	17.35	73	10	79	24	21	145	0.44	89.60	30.30	334	13.30	235	6.70	4.91
Kurtosis	1.72	−0.58	−0.47	1.18	8.37	29.30	2.23	−0.25	0.60	2.55	5.34	0.20	2.66	−0.23	1.79	1.22
Maximum	2627	19.31	83	26	250	216	61	181	0.56	101.90	34.10	362	16.80	392	13.20	6.31
Minimum	47	15.14	64	4	45	8	5	121	0.38	70.20	21.70	304	11.90	120	4.00	3.77

Figure 2. Changes in bilirubinaemia and Lp(a) with increment in haemoglobin.

Figure 3. Changes in bilirubinaemia and Lp(a) with increment in blood viscosity.

Table 2. Output of correlations analysis

	WBV	Lp(a)	SB	ALP	ALT	AST
WBV	1.000
Lp(a)	−0.005	1.000
SB	0.309	−0.016	1.000
ALP	0.163	0.108	−0.066	1.000
ALT	0.069	0.073	0.120	0.290	1.000
AST	0.067	−0.130	0.161	0.091	0.547	1.000
HGB	0.330	−0.258	0.161	0.038	0.204	0.019
HCT	0.389	−0.164	0.111	0.004	0.190	0.024
MCV	0.105	−0.052	−0.187	0.014	0.048	0.174
MCH	0.075	−0.181	−0.088	0.070	0.089	0.149
MCHC	−0.065	−0.268	0.147	0.088	0.077	0.000
RDW	0.184	0.060	0.214	0.176	0.238	0.233
PLT	−0.371	0.015	−0.171	0.203	0.026	−0.020
WBCC	−0.336	−0.012	−0.176	0.179	0.052	0.218
RBC	0.248	−0.089	0.230	−0.012	0.127	−0.088

Table 3. Absolute value results of three cases that had follow-up tests

		Lp(a)	WBV	SB	HGB
Case 1	1st record	379	17.05	12	146
	2nd record	708	17.15	9	143
Case 2	1st record	911	19.04	22	141
	2nd record	1078	18.53	10	135
Case 3	1st record	1107	17.58	5	154
	2nd record	885	16.15	6	152