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HEMATOLOGICAL MALIGNANCY

Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): Clinical and biological features and comparison with other acute myeloid leukemias with cytogenetic aberrations involving long arm of chromosome 3

Jose Maria RayaDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, SpainCorrespondence[email protected]

Taida Martín-SantosDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Elisa LuñoDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Carmen SanzoDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Maria Luz Perez-SirventDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Esperanza SuchDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

José Tomás NavarroDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Fuensanta MilláDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Esther AlonsoDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Alicia DomingoDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

María RozmanDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Marina Díaz-BevaDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Ana BatlleDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Sonia González-de-VillambrosiaDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Esperanza TusetDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

Teresa VallespíDepartment of HematologyHospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Spain

& On behalf of the Grupo Español de Citología Hematológica (GECH), Working Group into the Sociedad Española de Hematología y Hemoterapia (SEHH) show all

Figures & data

Table 1. Specific cytogenetic abnormalities in patients who constitute the group of AML abn(3q)

Display Table

Figure 1. AML with t(3;3)(q21;q26.2). Presence of blasts and dysplastic megakaryocytes in aspirate smear (Wright, x400).

Figure 2. AML with inv(3)(q21q26.2). Bone marrow biopsy showing a marked increase of atypical small mono- and bilobated megakaryocytes (PAS, x400).

Table 2. Main characteristics at diagnosis of the patients in the group of AML with inv(3)(q21q26) or t(3;3)(q21;q26) vs. those with AML carrying other 3q21 or 3q26 abnormality

Display Table

Table 3. Immunophenotypic features of blasts in AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2), and those from patients with AML carrying other cytogenetic aberrations involving 3q21 or 3q26

Display Table

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Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): Clinical and biological features and comparison with other acute myeloid leukemias with cytogenetic aberrations involving long arm of chromosome 3

Table 1. Specific cytogenetic abnormalities in patients who constitute the group of AML abn(3q)

Table 2. Main characteristics at diagnosis of the patients in the group of AML with inv(3)(q21q26) or t(3;3)(q21;q26) vs. those with AML carrying other 3q21 or 3q26 abnormality

Table 3. Immunophenotypic features of blasts in AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2), and those from patients with AML carrying other cytogenetic aberrations involving 3q21 or 3q26

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Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): Clinical and biological features and comparison with other acute myeloid leukemias with cytogenetic aberrations involving long arm of chromosome 3

Figures & data

Table 1. Specific cytogenetic abnormalities in patients who constitute the group of AML abn(3q)

Table 2. Main characteristics at diagnosis of the patients in the group of AML with inv(3)(q21q26) or t(3;3)(q21;q26) vs. those with AML carrying other 3q21 or 3q26 abnormality

Table 3. Immunophenotypic features of blasts in AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2), and those from patients with AML carrying other cytogenetic aberrations involving 3q21 or 3q26

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