Islet transplantation: learning from the Edmonton experience

Figures & data

Figure 1. Schematic representation of the basic steps of islet transplantation.

1. Retrieval of donor pancreas and isolation of islets by enzymatic and mechanical digestion. 2. Purification of islets using density gradient centrifugation. 3. Infusion of purified islets into the portal vein via percutaneous catheterization. 4. Implantation of infused islets in hepatic sinusoids.

Modified from the University of Alberta Clinical Islet Transplant Program [101].

Figure 2. Survival analysis for C-peptide secretion (A) and insulin independence (B) over time for all those who completed islet transplant procedures between April 1999 and November 2004 at the University of Alberta.

The survival curves are dated from the time of the final transplant.

^©2005 American Diabetes Association, adapted from [10].

University of Alberta Clinical Islet Transplant Program www.med.ualberta.ca/islet

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Ryan EA, Paty BW, Senior PA et al. Five-year follow-up after clinical islet transplantation. Diabetes54, 2060–2069 (2005).

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