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Editorial

Islet transplantation: learning from the Edmonton experience

‘Since the introduction of steroid-free immunosuppressive regimens in the late 1990s, the 1-year insulin independence rate observed in islet transplant recipients has risen from less than 10 to approximately 80%’

Pages 315-318 | Published online: 10 Jan 2014

References

  • Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med.343, 230–238 (2000).
  • Robertson RP. Islet transplantation as a treatment for diabetes – a work in progress. N. Engl. J. Med.350, 694–705 (2004).
  • Shapiro AM, Hering B, Ricordi C et al. International multicenter trial of islet transplantation using the edmonton protocol in patients with type I diabetes. Am. J. Transplant.3(Suppl. 5), 152 (2003).
  • Barshes NR, Lee T, Goodpasture S et al. Achievement of insulin independence via pancreatic islet transplantation using a remote isolation center: a first-year review. Transplant Proc.36, 1127–1129 (2004).
  • Korsgren O, Nilsson B, Berne C et al. Current status of clinical islet transplantation. Transplantation79, 1289–1293 (2005).
  • Moberg L, Johansson H, Lukinius A et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet360, 2039–2045 (2002).
  • Johansson H, Lukinius A, Moberg L et al. Tissue factor produced by the endocrine cells of the islets of langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes54, 1755–1762 (2005).
  • American Diabetes Association. Pancreas transplantation for patients with diabetes. Diabetes Care27, S105 (2004).
  • Ryan EA, Lakey JR, Paty BW et al. Successful islet transplantation: continued insulin reserve provides long term control. Diabetes51, 2148–2157 (2002).
  • Ryan EA, Paty BW, Senior PA et al. Five-year follow-up after clinical islet transplantation. Diabetes54, 2060–2069 (2005).
  • Bonner-Weir S. β-cell turnover: its assessment and implications. Diabetes50(Suppl. 1), S20–S24 (2001).
  • Paty BW, Senior PA, Lakey JR, Shapiro AM, Ryan EA. Assessment of glycemic control after islet transplantation using the continuous glucose monitor in insulin-independent versus insulin-requiring type 1 diabetes subjects. Diabetes Technol. Ther. (2006) (In Press).
  • Fiorina P, Gremizzi C, Maffi P et al. Islet transplantation is associated with an improvement of cardiovascular function in type 1 diabetic kidney transplant patients. Diabetes Care28, 1358–1365 (2005).
  • Lee TC, Barshes NR, O’Mahony CA et al. The effect of pancreatic islet transplantation on progression of diabetic retinopathy and neuropathy. Transplant Proc.37, 2263–2265 (2005).
  • Villiger P, Ryan EA, Owen R et al. Prevention of bleeding after islet transplantation: lessons learned from a multivariate analysis of 132 cases at a single institution. Am. J. Transplant5, 2992–2998 (2005).
  • Casey JJ, Lakey JR, Ryan EA et al. Portal venous pressure changes after sequential clinical islet transplantation. Transplantation74, 913–915 (2002).
  • Markmann JF, Rosen M, Siegelman ES et al. Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: a functional footprint of islet graft survival? Diabetes52, 1591–1594 (2003).
  • Bhargava R, Senior PA, Ackerman TE et al. Prevalence of hepatic steatosis after islet transplantation and its relation to graft function. Diabetes53, 1311–1317 (2004).
  • Senior P, Zeman M, Paty B, Shapiro A, Ryan E. Renal outcomes after clinical islet allotransplantation at the University of Alberta – 4 year follow-up. Diabetes 53, A69 (2004).

Website

  • University of Alberta Clinical Islet Transplant Program www.med.ualberta.ca/islet

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