Chronic Low Back pain, Modic Changes and low-grade Virulent Infection: Efficacy of Antibiotic Treatment

Figures & data

Table 1. A comparison of outcome measures at baseline and 1-year follow-up for patients with Modic changes type 1 in the Albert and Bråten trials.

	Albert et al., Modic type 1, n = 162 ^†					Bråten et al., Modic type 1, n = 118 ^‡
	Baseline		1 year			Baseline		1 year			[29,30]
	Placebo	Antibiotic	Placebo	Antibiotic	p-value	Placebo	Antibiotic	Placebo	Antibiotic	p-value
RMDQ score	15.0 (12;18)	15.0 (11;18)	14.0 (11;18)	7 (4;11)	0.0001	12.3 (3.7)	12.9 (4.3)	10.3 (5.4)	8.2 (6.0)	0.02
LBP score	6.3 (4.7;8)	6.7 (5.3;7.0)	6.3 (4;7.7)	3.7 (1.3;5:8)	0.0004	6.3 (1.3)	6.5 (1.1)	5.2 (2.2)	4.5 (2.5)	0.06
EQ-5D score	60 (40;75)	59 (40;70)	60 (40;75)	75 (54;90)	0.0014	56 (0.16)	55 (0.18)	60 (0.21)	66 (0.21)	0.03

† Values are presented as median and lower; upper quartiles.

‡ Values presented as mean and standard deviations.

EQ-5D: EuroQol- 5 Dimension; LBP: Lower back pain; RMDQ: Roland–Morris Disability Questionnaire.

Table 2. An overview of the nonrandomized studies.

Study (year)	n	MC1/MC2	Drop-outs	Primary outcome parameter	Follow-up (months)	Adverse effect report	Ref.
Albert et al. (2008)	32	MC1	3	RMDQ23	12/12	Yes	[33]
Albert et al. (2017)	1024	MC1 or MC2	37	RMDQ23	24/12	No	[34]
Hammond et al. (2015)	30	NS	8	RMDQ23	3/12	Yes	[35]
Manniche et al. (2016)	147	MC1	0	Patients Global Assessment	6/12	Yes	[36]
Palazzo et al. (2017)	28	MC1	8	Patients Global Assessment	12/12	Yes	[37]
Schepers et al. (2019)	30	NS	0	RMDQ	12/12	Yes	[38]
Gupta et al.(2017)	11	NS	NS	Pain, Numeric Rating Scale	11/11	NS	[39]

MC: Modic changes; NS: Not stated; RMDQ: Roland–Morris disability questionnaire.

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