Positive margins (R1) risk factors in breast cancer conservative surgery

Figures & data

Figure 1 Overall survival by margins (R0= free margins, R1= positive margins) (n. s.).

Abbreviations: dd, days; ns, not significant.

Table 1 Characteristics of the sample

Characteristic	Total sample	R0 (n=1293)	R1 (n=143)	Significance
Age (yy, avg±stddev)	58.8 (±12.24)	59.12 (±12.3)	55.7 (±11.5)	P< 0.01
Localization, quadrant (%)
Upper-Outer	40	40	39	N.S.
Upper-Inner	24	24	22
Lower-Outer	18	18	19
Lower-Inner	13	13	15
Central portion	5	5	5
Surgical technique (%)
Classic (Veronesi)	43	44	37	N.S.
oncoplastic	57	56	63
Histological size
(Mm,avg±stddev)	14.8 (±8.7)	14.5 (±8.1)	17.4 (±12.5)	P< 0.01
Histological class (%)
Lobular	11	11	18	P< 0.01
Ductal	84	85	74
Other	5	4	8
Grading (%)
G1	30	31	27	P< 0.05
G2	38	36	49
G3	32	33	24
Multifocality(%)	12	8,5	47	P<0.000
Molecular subtype (%)
Luminal A	40	39	44	N.S.
Luminal B	44	45	44
Triple Neg	8	8	4
Her2	8	8	8
Lympho-vascular invasion (%)
No	91	92	84	P< 0.05
Yes	9	8	16
Lymph node status(%)
N0	76	77	66	P< 0.05
N+	24	23	34

Abbreviations: Yy, years; Avg, average; Stddev, standard deviation; mm, millimeters; R0, free margins; R1, positive margins.

Table 2 Multivariate analysis

Linear statistical model	Deviance	P
Age	10.5979	0.001132
Localization	1.8202	0.873421
Surgical technique (oncoplastic)	1.2657	0.260571
Age: localization	6.9735	0.137293
Age: oncoplastic	4.156	0.033579
Localization: oncoplastic	3.5235	0.47432
Age: Localization: oncoplastic	2.722	0.605374