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Original Research

The Predictive Effect of the 8th AJCC Pathological Prognostic Staging on the Benefit of Postmastectomy Radiotherapy in N2/N3 Breast Cancer

, , , ORCID Icon &
Pages 133-144 | Published online: 13 May 2022

Figures & data

Table 1 Patients’ Baseline Demographic and Clinicopathological Characteristics

Figure 1 Flow diagram of the study cohort.

Abbreviations: AJCC, American Joint Committee on Cancer; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; N, node; M, metastasis; PMRT, postmastectomy radiotherapy; PR, progesterone receptor; T, tumor.
Figure 1 Flow diagram of the study cohort.

Table 2 The Frequency of Stage Discrepancies Among Individual Patients

Figure 2 Receiver operating characteristics analyses for comparing the prognostic abilities between the 7th anatomic staging and 8th pathological prognostic staging.

Abbreviation: AJCC, American Joint Committee on Cancer.
Figure 2 Receiver operating characteristics analyses for comparing the prognostic abilities between the 7th anatomic staging and 8th pathological prognostic staging.

Figure 3 Kaplan–Meier survival curves of the 7th anatomic staging (A) and 8th pathological prognostic staging (B).

Abbreviations: AJCC, American Joint Committee on Cancer.
Figure 3 Kaplan–Meier survival curves of the 7th anatomic staging (A) and 8th pathological prognostic staging (B).

Table 3 Multivariate Prognostic Analysis in the Entire Cohort

Table 4 Multivariate Prognostic Analysis in the Entire Cohort, Including the 8th Pathological Prognostic Staging

Table 5 Sensitivity Analyses of Postmastectomy Radiotherapy Receipt on Breast Cancer-Specific Mortality Using the Cox Regression Models

Figure 4 The effect of postmastectomy radiotherapy on breast cancer-specific survival according to the 7th anatomic staging ((A) stage IIIA disease; (B) stage IIIB disease; (C) stage IIIC disease).

Abbreviation: PMRT, postmastectomy radiotherapy.
Figure 4 The effect of postmastectomy radiotherapy on breast cancer-specific survival according to the 7th anatomic staging ((A) stage IIIA disease; (B) stage IIIB disease; (C) stage IIIC disease).

Figure 5 The effect of postmastectomy radiotherapy on breast cancer-specific survival according to the 8th pathological prognostic staging ((A) stage IB disease; (B) stage IIA disease; (C) stage IIB disease; (D) stage IIIA disease; (E) stage IIIB disease; (F) stage IIIC disease).

Abbreviation: PMRT, postmastectomy radiotherapy.
Figure 5 The effect of postmastectomy radiotherapy on breast cancer-specific survival according to the 8th pathological prognostic staging ((A) stage IB disease; (B) stage IIA disease; (C) stage IIB disease; (D) stage IIIA disease; (E) stage IIIB disease; (F) stage IIIC disease).