Galanin Receptors as Drug Target for Novel Antidepressants: Review

Figures & data

Table 1 Effects of Galanin Receptor Ligands and Animal Models in Rodent Test of Depression

Ligand	Model	Species	Dose	Effect	Reference
WAY100635-5-5HT1AR antagonist	FST	Rats	6nmol	↓(GAL(1–15)/FLX)	^Citation81
M35-nonselective GAL receptor antagonist	FST	Mouse	4 ug	↑	^Citation17
J18-selective GALR2 agonist	FST	Mouse	0.25 mg/kg	↑	^Citation17
J20-selective GALR2 agonist	FST	Mouse	0.5 mg/k	↑	^Citation17
M1160-selective GALR2 agonist	TST	Mouse	4 ug	↑	^Citation17
siRNA GAL2	TST	Rats	5 μg	0	^Citation46
	FST	Rats	5 μg	0	^Citation46
siRNA GAL1	TST	Rats	5 μg	0	^Citation46,Citation72
	FST	Rats	5 μg	0	^Citation46,Citation72
8-OH-DPAT-5-HT1AR agonist	FST	Rats	0.125 mg/kg, 0.25 mg/kg	Synergize with Gal1-15	^Citation48
GAL2-antagonist (M871)	FST	Rats	1.0nmol	↓	^Citation85
GAL2 agonist(AR-M1896)	FST	Rats	1.0nmol	↑	^Citation85
GAL1 agonist(M617)	FST	Rats	1.0nmol	0	^Citation85
GAL(1–29)	FST	Rats	0.3nmol	↑	^Citation85
GAL(1–15)1nmol+ FLX(10mg/kg)	FST	Rats		↑	^Citation81

Abbreviations: GAL, Galanin; FLX, Fluoxetine; FST, Forced Swimming Test; TST, Tail Suspension Test; siRNA GAL1 or 2, Knocked down Galanin 1 or 2 Receptor; 5-HT1AR, 5-Hydroxy Tryptamine 1A Receptor.

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