The Effectiveness of a New Topical Formulation Containing GSH-C4 and Hyaluronic Acid in Seborrheic Dermatitis: Preliminary Results of an Exploratory Pilot Study

Figures & data

Table 1 Clinical Evaluation Parameters

Scale	0—Absent	1—Mild	2—Moderate	3—Severe	4—Very severe
Erythema	0—Absent	1—Mild	2—Moderate	3—Severe	4—Very severe
Pruritus	0—Absent	1—Mild	2—Moderate	3—Severe	4—Very severe
Provider Global Assessment	0—Clear	1—Almost clear	2—Mild	3—Moderate	4—Severe

Figure 1 Patient at baseline T0 and T4. In the yellow circle it is possible to see the complete regression of the inflamed and desquamated area (yellow arrows).

Figure 2 Patient at T0 (left) and T4 (right). Here we can notice the local inflammation has reduced (yellow circle), whilst the skin watermark has improved (yellow arrows).

Table 2 Investigator Global Assessment (IGA) Score by Retrospective Review of Clinical Charts and Photographs and Patient Global Assessment of Treatment (PGA) Based on 5-Point Likert Scale

		Medium IGA Score T0 (Median)	Medium IGA Score T2 (Median)	Medium IGA Score T4 (Median)	Medium PVAS Score T0 (Median)	Medium PVAS Score T2 (Median)	Medium PVAS Score T4 (Median)	Medium DLQI Score T0 (Median)	Medium DLQI Score T2 (Median)	Medium DLQI Score T4 (Median)
Total patients	20	3.35 (4)	1.35 (2)	0,4 (0)	4.25 (4)	2.25 (2)	0,6 (0)	19.25 (19)	0 (0)	0 (0)
Male (number)	65% (13)	2.46 (3)	0.65 (2)	0,2 (0)	4.08 (4)	2 (2)	0.35 (0)	20 (20)	0 (0)	0 (0)
Female (number)	35% (7)	3.28 (4)	1.57 (2)	0.57 (1)	4.57 (4)	2.43 (3)	0.25 (1)	17.86 (17)	0 (0)	0 (0)

For IGA, we rated overall severity on a 0-to-4 scale as 0 1/4 clear, 1 1/4 almost clear, 2 1/4 mild, 3 1/4 moderate, and 4 1/4 severe. We considered treatment to be successful when lesions cleared or were almost cleared. Subjects were considered successfully treated if the erythema and scaling as well as investigator global assessment (IGA) scores decreased to 0 (or 1 if the baseline score was > or =3).