Anti-Tumor Activities of Bioactive Phytochemicals in Sophora flavescens for Breast Cancer

Figures & data

Table 1 General Information of Active Ingredients in Sophora flavescens for Breast Cancer

	Chemical Formula	Types of Cancer Cells	Optimum Experimental Concentration	Effects	Side Effects	Molecular Weight
Compound Kushen Injection	Include MT, OMT, sophoridine and oxysophocarpine, et al	MDA-MB-231, MCF-7	2 mg/mL	Reduce cell migration, induce cell apoptosis, reduce energy consumption, anti-angiogenesis, overcome the multidrug resistance, improve the efficiency of chemotherapy, reduce adverse reactions of chemotherapy	Unclear	N
Matrine	C15H24N2O	Bcap-37, MCF-7/ADR, BT-474, MDA-MB-231, 4T1	In vivo: 10mg/Kg In vitro: 50–100 μg/mL	Induce apoptosis of cells, inhibit the tumor vascular formation, protect liver function of breast cancer patients undergoing chemotherapy, down-regulate expression level of miRNA	Unclear	248.36g/mol
Oxymatrine	C15H24N2O2	MCF-7, MDA-MB-231	100 μg/mL	Induce apoptosis of cells, inhibit epithelial-mesenchymal transformation of cells	Unclear	264.37g/mol
kurarinone	C26H30O6	MDA-MB-453S, MCF-7, Bcap-37	7.3 and 31 µg/mL	Enhance antitumor activities of taxol, suppress cell proliferation	Unclear	438.52 g/mol
2ʹ-methoxy-kurarinone	C27H32O6	MDA-MB-453S, MCF-7, Bcap-37	7.3 and 31 µg/mL	Enhance antitumor activities of taxol, suppress cell proliferation	Unclear	452.55g/mol
Sophoridine	C15H24N2O	MCF-7	30µg/mL	Antiproliferative activity	Unclear	248.37g/mol
Sophoridine+COCH2Br	C17H26N2O2Br	MCF-7	20µg/mL	Antiproliferative activity, suspend the cell cycle	Unclear	370.31g/mol
9-methylanthracene+CH2OH	C16H2O	MCF-7/AMD	1.25–5.0µg/mL	Block cell cycle	Unclear	210.19 g/mol
12-N-p-Chlorobenzyl sophoridinic-4ʹ,4- chlorophenyl ketone	C28H34ON2Cl2	MCF-7/AMD	1.25–5.0µg/mL	Block cell cycle	Unclear	485.50 g/mol
−4ʹ-4ʹ-diethyl sophoridinene bihydrochloride	C26H39N2Cl·2HCl	MCF-7/AMD	1.25–5.0µg/mL	Block cell cycle	Unclear	486.98g/mol
Matrine+ methyl 6‑bromo‑2‑naphthoate	C26H9N2O2Br	BT-20, MCF-7	12.5, 25, 50 µM	Induce apoptosis and oxidative stress	Unclear	461.27 g/mol
5,7,D, 2ʹ,4ʹ-tetrahydroxy-8-lavandulylflavano	C25H28O6	MDA-MB-231	0-30µM	Increase cell apoptosis	Unclear	423.18 g/mol