Anti-Tumor Activities of Bioactive Phytochemicals in Sophora flavescens for Breast Cancer

References

• Chui CH, Lau FY, Tang JC, et al. Activities of fresh juice of Scutellaria barbata and warmed water extract of Radix Sophorae Tonkinensis on anti-proliferation and apoptosis of human cancer cell lines. Int J Mol Med. 2005;16:337–341.16012772
   PubMed Web of Science ®Google Scholar
• Greenlee H, DuPont-Reyes MJ, Balneaves LG, et al. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 2017;67:194–232. doi:10.3322/caac.2139728436999
   PubMed Web of Science ®Google Scholar
• Li J, Liu X, Chen H, et al. Multi-targeting chemoprevention of Chinese herb formula Yanghe Huayan decoction on experimentally induced mammary tumorigenesis. BMC Complement Altern Med. 2019;19:48. doi:10.1186/s12906-019-2456-130760265
   PubMed Web of Science ®Google Scholar
• Zhuang SR, Chiu HF, Chen SL, et al. Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients. Br J Nutr. 2012;107:712–718. doi:10.1017/S000711451100345X21864416
   PubMed Web of Science ®Google Scholar
• Zhao X, Liu J, Ge S, et al. Saikosaponin A inhibits breast cancer by regulating Th1/Th2 balance. Front Pharmacol. 2019;10:624. doi:10.3389/fphar.2019.0062431214035
   PubMed Web of Science ®Google Scholar
• Iwanowycz S, Wang J, Hodge J, Wang Y, Yu F, Fan D. Emodin inhibits breast cancer growth by blocking the tumor-promoting feedforward loop between cancer cells and macrophages. Mol Cancer Ther. 2016;15:1931–1942. doi:10.1158/1535-7163.MCT-15-098727196773
   PubMed Web of Science ®Google Scholar
• Wang Z, Loo WT, Wang N, et al. Effect of Sanguisorba officinalis L on breast cancer growth and angiogenesis. Expert Opin Ther Targets. 2012;16(Suppl 1):S79–S89. doi:10.1517/14728222.2011.64237122316502
   PubMedGoogle Scholar
• Li J, Wu Y, Wang D, et al. Oridonin synergistically enhances the anti-tumor efficacy of doxorubicin against aggressive breast cancer via pro-apoptotic and anti-angiogenic effects. Pharmacol Res. 2019;146:104313. doi:10.1016/j.phrs.2019.10431331202781
   PubMed Web of Science ®Google Scholar
• Huang L, Li A, Liao G, et al. Curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer MDA-MB 231 cells via activation of p73 and PUMA. Oncol Lett. 2017;14:1080–1088. doi:10.3892/ol.2017.627328693277
   PubMed Web of Science ®Google Scholar
• Patel A, Soni A, Siddiqi NJ, Sharma P. An insight into the anticancer mechanism of Tribulus terrestris extracts on human breast cancer cells. 3 Biotech. 2019;9:58. doi:10.1007/s13205-019-1585-z
   PubMedGoogle Scholar
• Deng Y, Li F, He P, et al. Triptolide sensitizes breast cancer cells to Doxorubicin through the DNA damage response inhibition. Mol Carcinog. 2018;57:807–814. doi:10.1002/mc.v57.629500880
   PubMed Web of Science ®Google Scholar
• Greenshields AL, Fernando W, Hoskin DW. The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells. Exp Mol Pathol. 2019;107:10–22. doi:10.1016/j.yexmp.2019.01.00630660598
   PubMed Web of Science ®Google Scholar
• von Hagens C, Walter-Sack I, Goeckenjan M, et al. Long-term add-on therapy (compassionate use) with oral artesunate in patients with metastatic breast cancer after participating in a phase I study (ARTIC M33/2). Phytomedicine. 2019;54:140–148. doi:10.1016/j.phymed.2018.09.17830668363
   PubMed Web of Science ®Google Scholar
• Li X, Wang W, Fan Y, et al. Anticancer efficiency of cycloartane triterpenoid derivatives isolated from Cimicifuga yunnanensis Hsiao on triple-negative breast cancer cells. Cancer Manag Res. 2018;10:6715–6729. doi:10.2147/CMAR.S18538730584366
   PubMed Web of Science ®Google Scholar
• Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and their bioactive phytochemicals for women’s health. Pharmacol Rev. 2016;68:1026–1073. doi:10.1124/pr.115.01084327677719
   PubMed Web of Science ®Google Scholar
• Sun M, Cao H, Sun L, et al. Antitumor activities of Kushen: literature review. Evid Based Complement Altern Med. 2012;2012:373219. doi:10.1155/2012/373219
   PubMed Web of Science ®Google Scholar
• Jin Y, Yang Q, Liang L, et al. Compound Kushen Injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway. J Exp Clin Cancer Res. 2018;37:277. doi:10.1186/s13046-018-0948-330454068
   PubMed Web of Science ®Google Scholar
• Tu H, Lei B, Meng S, et al. Efficacy of Compound Kushen Injection in combination with induction chemotherapy for treating adult patients newly diagnosed with acute leukemia. Evid Based Complement Altern Med. 2016;2016:3121402. doi:10.1155/2016/3121402
   PubMed Web of Science ®Google Scholar
• Zhang J, Qu Z, Yao H, et al. An effective drug sensitizing agent increases gefitinib treatment by down regulating PI3K/Akt/mTOR pathway and up regulating autophagy in non-small cell lung cancer. Biomed Pharmacother. 2019;118:109169. doi:10.1016/j.biopha.2019.10916931310954
   PubMed Web of Science ®Google Scholar
• Wang XQ, Liu J, Lin HS, Hou W. A multicenter randomized controlled open-label trial to assess the efficacy of Compound Kushen Injection in combination with single-agent chemotherapy in treatment of elderly patients with advanced non-small cell lung cancer: study protocol for a randomized controlled trial. Trials. 2016;17:124.26956875
   PubMed Web of Science ®Google Scholar
• Gao L, Wang KX, Zhou YZ, Fang JS, Qin XM, Du GH. Uncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validation. Sci Rep. 2018;8:624. doi:10.1038/s41598-017-18325-729330507
   PubMed Web of Science ®Google Scholar
• Nourmohammadi S, Aung TN, Cui J, et al. Effect of Compound Kushen Injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain, and breast cancer cell lines. Front Oncol. 2019;9:314. doi:10.3389/fonc.2019.0031431106149
   PubMed Web of Science ®Google Scholar
• Qu Z, Cui J, Harata-Lee Y, et al. Identification of candidate anti-cancer molecular mechanisms of Compound Kushen Injection using functional genomics. Oncotarget. 2016;7:66003–66019. doi:10.18632/oncotarget.v7i4027602759
   PubMedGoogle Scholar
• Cui J, Qu Z, Harata-Lee Y, et al. Cell cycle, energy metabolism and DNA repair pathways in cancer cells are suppressed by Compound Kushen Injection. BMC Cancer. 2019;19:103. doi:10.1186/s12885-018-5230-830678652
   PubMed Web of Science ®Google Scholar
• Xu W, Lin H, Zhang Y, et al. Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/beta-catenin pathway. J Exp Clin Cancer Res. 2011;30:103. doi:10.1186/1756-9966-30-10322032476
   PubMed Web of Science ®Google Scholar
• Wang H, Hu H, Rong H, Zhao X. Effects of Compound Kushen Injection on pathology and angiogenesis of tumor tissues. Oncol Lett. 2019;17:2278–2282. doi:10.3892/ol.2018.986130719109
   PubMed Web of Science ®Google Scholar
• Li HY, Chen Y, He QY. Mechanisms of yanshu injection for overcoming multidrug resistance in breast carcinoma MCF-7 cells: an experimental research. Chin J Integr Med. 2014;34:324–328.
   Google Scholar
• Long Y, Zeng ZT, Li YC, Li D. Effect of compound matrine injection in the model rats of breast cancer. Chin J Clin Pharmacol. 2018;34:141–144.
   Google Scholar
• Lai MH. Improvement of compound matrine injection in breast cancer model rat. Chin J Clin Pharmacol. 2017;33:244–247.
   Google Scholar
• Hou G, Li N, Zhang YP, Xiao CH, Wang C, Liu ZW. Expression of Survivin in breast cancer and study on the effectiveness of matrine. Mod Oncol. 2018;26:388–391.
   Google Scholar
• Wen B, Yang ZH, Zheng WT. Clinical significance of changes of serum VEGF-A in breast cancer patients with combination with radiotherapy and matrine. Chin J Lab Diagn. 2011;15:1916–1917.
   Google Scholar
• Fu FM, Luo SH, Wang Y, et al. Meta-analysis the effect of Fufangkushen injection combined with chemotherapy on immune function in patients with breast cancer. Pract Clin J Integr Tradit Chin West Med. 2018;18:1-4+22.
   Google Scholar
• Gu XD, Zhao H, Xie XH. Effect of Compound Kushen Injection combined with neoadjuvant chemotherapy for locally advanced breast cancer. Zhejiang J Tradit Chin Med. 2015;50:74.
   Google Scholar
• Zhai XJ. Effects of Compound Kushen Injection on immune function and toxicity reaction of patients with postoperative chemotherapy for breast cancer. Chin J Basic Medi Tradit Chin Med. 2014;20:829–831.
   Google Scholar
• Wei PF, Chen MX, Yang YY, Zhang YM, Wang J, Wang HC. Clinical effect of postoperative radiotherapy combined with compound matrine injection on the patients with breast cancer. Prog Mod Biomed. 2017;17:5255-7+66.
   Google Scholar
• Maimaitiniyazi S, Ai XQ, Zhu XL, Wang YH, Mushajiang M. Effects of compound Kushen Injection combined with postoperative radiotherapy on immune function and quality of life for breast cancer. Hainan MED J. 2016;27:2283–2285.
   Google Scholar
• Yasheng A, Ai XY, Zhang JZN, Tong Y, Wu J, Zhao B. Toxic and side effects of compound matrine injection in breast cancer adjuvant chemotherapy. Liaoning J Tradit Chin Med. 2016;43:2101–2102.
   Google Scholar
• Chen LJ. Efficacy analysis of Compound Kushen Injection as adjunctive treatment for breast cancer. China Pharm. 2010;21:1866–1867.
   Google Scholar
• An AJ, An GW, Wu YC. Observation of compound recipe light yellow sophora root injecta combined with chemotherapy in treatment of 35 postoperative patients with breast cancer. Med Pharm J Chin PLA. 2012;24:43–46.
   Google Scholar
• Wang YX. Clinical observation of Compound Kusheng Injection combined with chemotherapy in treatment of three negative breast cancer. World Latest Med Inf. 2018;18:3–4.
   Google Scholar
• Gao QF. Clinical observation of Compound Kusheng Injection combined with postoperative chemotherapy for breast cancer. Liaoning J Tradit Chin Med. 2015;42:1928–1929.
   Google Scholar
• Bai ZQ. 63 cases of clinical observation research of zoleronic acid injection joint compound sophora injection on the treatment for breast cancer bone metastasis. Chin J Hosp Pharm. 2016;36:328–329.
   Google Scholar
• Wu J, Hu G, Dong Y, et al. Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells. J Cell Mol Med. 2017;21:1171–1181. doi:10.1111/jcmm.2017.21.issue-628026112
   PubMed Web of Science ®Google Scholar
• Xie M, He G, Wang R, et al. Matrine-induced apoptosis of human nasopharyngeal carcinoma cells via in vitro vascular endothelial growth factor-A/extracellular signal-regulated kinase1/2 pathway inactivation. Hormone Metab Res. 2014;46:556–560. doi:10.1055/s-00000025
   PubMed Web of Science ®Google Scholar
• Qian L, Liu Y, Xu Y, et al. Matrine derivative WM130 inhibits hepatocellular carcinoma by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways. Cancer Lett. 2015;368:126–134. doi:10.1016/j.canlet.2015.07.03526259512
   PubMed Web of Science ®Google Scholar
• Zhou H, Xu M, Gao Y, et al. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Mol Cancer. 2014;13:59. doi:10.1186/1476-4598-13-5924628719
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang S, Liu J, Fang B, Yao J, Cheng B. Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial mesenchymal transition. Mol Med Rep. 2018;18:911–919. doi:10.3892/mmr.2018.902329845189
   PubMed Web of Science ®Google Scholar
• Wu X, Zhou J, Cai D, Li M. Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway. Oncol Rep. 2017;38:1312–1320. doi:10.3892/or.2017.578728677790
   PubMed Web of Science ®Google Scholar
• Gu YY, Chen MH, May BH, et al. Matrine induces apoptosis in multiple colorectal cancer cell lines in vitro and inhibits tumour growth with minimum side effects in vivo via Bcl-2 and caspase-3. Phytomedicine. 2018;51:214–225. doi:10.1016/j.phymed.2018.10.00430466620
   PubMed Web of Science ®Google Scholar
• Yang Y, Guo JX, Shao ZQ, Gao JP. Matrine inhibits bladder cancer cell growth and invasion in vitro through PI3K/AKT signaling pathway: an experimental study. Asian Pac J Trop Med. 2017;10:515–519. doi:10.1016/j.apjtm.2017.05.00928647190
   PubMed Web of Science ®Google Scholar
• Zhang P, Wang Z, Chong T, Ji Z. Matrine inhibits proliferation and induces apoptosis of the androgen independent prostate cancer cell line PC-3. Mol Med Rep. 2012;5:783–787. doi:10.3892/mmr.2011.70122159447
   PubMed Web of Science ®Google Scholar
• Huang H, Wang Q, Du T, et al. Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B. Prostate. 2018;78:327–335. doi:10.1002/pros.v78.529356020
   PubMed Web of Science ®Google Scholar
• Xie W, Lu J, Lu Q, et al. Matrine inhibits the proliferation and migration of lung cancer cells through regulation of the protein kinase B/glycogen synthase kinase-3beta signaling pathways. Exp Ther Med. 2018;16:723–729. doi:10.3892/etm.2018.626630112033
   PubMed Web of Science ®Google Scholar
• Cho YR, Lee JH, Kim JH, et al. Matrine suppresses KRAS-driven pancreatic cancer growth by inhibiting autophagy-mediated energy metabolism. Mol Oncol. 2018;12:1203–1215. doi:10.1002/1878-0261.1232429791786
   PubMed Web of Science ®Google Scholar
• Wang D, Cao Y, Zheng L, et al. Identification of Annexin A2 as a target protein for plant alkaloid matrine. Chem Commun. 2017;53:5020–5023. doi:10.1039/C7CC02227A
   PubMed Web of Science ®Google Scholar
• Feng Q, Yang X, Hao Y, et al. Cancer cell membrane-biomimetic nanoplatform for enhanced sonodynamic therapy on breast cancer via autophagy regulation strategy. ACS Appl Mater Interfaces. 2019;11:32729–32738. doi:10.1021/acsami.9b1094831415145
   PubMed Web of Science ®Google Scholar
• Ren LL, Lan T, Wang XJ. Antitumor effect of matrine in human breast cancer Bcap-37 cells by apoptosis and autophagy. Chin Archiv Tradit Chin Med. 2014;32:2756–2759.
   Google Scholar
• Ren LL, Wang LL, Wang XJ. Relationship between matrine induced autophagy and mTOR in human breast cancer Bcap-37 cells. Zhejiang JITCWM. 2016;26:783–786.
   Google Scholar
• Zhou BG, Sun JZ, Su G, Ma DQ. Apoptosis of human breast cancer MCF-7/ADR cells induced by matrine. Chin J Exp Surg. 2003;20:515–516.
   Google Scholar
• Yu P, Liu Q, Liu K, Yagasaki K, Wu E, Zhang G. Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling. Cytotechnology. 2009;59:219–229. doi:10.1007/s10616-009-9225-919760125
   PubMed Web of Science ®Google Scholar
• Li H, Tan G, Jiang X, et al. Therapeutic effects of matrine on primary and metastatic breast cancer. Am J Chin Med (Gard City N Y). 2010;38:1115–1130. doi:10.1142/S0192415X10008512
   PubMed Web of Science ®Google Scholar
• Zheng RZ, Zhang JY, Shao XY, Wang XJ. Mechanism of matrine promoting apoptosis induced by tamoxifen in breast cancer cell Bcap-37. J Chin Oncol. 2012;18:840–843.
   Google Scholar
• Zheng RZ, Zhang JY, Shao XY, Wang XJ. Inhibition of the growth of human breast cancer cell line Bcap-37 with matrine. Zhejiang JITCWM. 2012;22:945–947.
   Google Scholar
• Li HJ, Zhao XX, Bai ML, Zhang LX, Liu H, Ge LP. Effects of matrine on proliferation and apoptosis in human breast cancer MCF-7 cells. Jiangsu Med J. 2011;37:396-8+68.
   Google Scholar
• Xiao X, Ao M, Shi WD, et al. The effect of matrine on proliferation and apoptosis in breast cancer MCF-7 cells. Chin Tradit Patent Med. 2018;40:2750–2754.
   Google Scholar
• Sui H. Effects of matrine on proliferation of human breast cancer cells. China J Mod Med. 2013;23:41–43.
   Google Scholar
• Wang SQ, Guo Y, Li HJ, Zhang XL, Li YZ, Hao XQ. Matrine induces apoptosis in MCF-7 breast cancer cells and it’s effect on Bax. Chin J Gerontol. 2012;32:3489–3491.
   Google Scholar
• Zhao WG, Sun Y, Zhuang J, Feng FB, Li J, Sun CG. Matrine with adriamycin has synergistic effect on human breast cancer cells. Lishizhen Med Mater Med Res. 2018;29:33–36.
   PubMedGoogle Scholar
• Zhou BG, Wei CS, Zhang S, Zhang Z, Gao HM. Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway. J Cell Biochem. 2018;119:3885–3891. doi:10.1002/jcb.2650229130495
   PubMed Web of Science ®Google Scholar
• Li H, Li X, Bai M, Suo Y, Zhang G, Cao X. Matrine inhibited proliferation and increased apoptosis in human breast cancer MCF-7 cells via upregulation of Bax and downregulation of Bcl-2. Int J Clin Exp Pathol. 2015;8:14793–14799.26823806
   PubMed Web of Science ®Google Scholar
• Xiao X, Ao M, Xu F, et al. Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/beta-catenin pathway. Oncol Lett. 2018;15:1691–1697. doi:10.3892/ol.2017.751929434864
   PubMed Web of Science ®Google Scholar
• Shao H, Yang B, Hu R, Wang Y. Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-kappaB signaling pathway. Oncol Lett. 2013;6:517–520. doi:10.3892/ol.2013.139924137358
   PubMed Web of Science ®Google Scholar
• Xiao Y, Ma D, Wang H, et al. Matrine suppresses the ER-positive MCF cells by regulating energy metabolism and endoplasmic reticulum stress signaling pathway. Phytother Res. 2017;31:671–679. doi:10.1002/ptr.v31.428185329
   PubMed Web of Science ®Google Scholar
• Gu MR, Li JB, Zhang XH, Yin YM. Analysis of induced apoptosis effect of matrine on human breast cancer MCF-7 cell and its effect on mitochondrial transmembrane potential. Chin J Biochem Pharm. 2015;35:39–41.
   Google Scholar
• Li HJ, Zhao XX, Bai ML, Zhang LX, Li YZ, Liu H. The effect of matrine on apoptosis and mitochondrial transmembrane potential in MCF-7 cells. Lishizhen Med Mater Med Res. 2011;22:2042–2043.
   Google Scholar
• Shi WD, Li DX, Hu JL, Wang Y, Yang N, Xiao X. Matrine inhibits proliferation of breast cancer 4T1 cells by regulating expression of annexin A3. Ningxia Med J. 2019;9:967–969.
   Google Scholar
• Li LQ, Li XL, Wang L, et al. Matrine inhibits breast cancer growth via miR-21/PTEN/Akt pathway in MCF-7 cells. Cell Physiol Biochem. 2012;30:631–641. doi:10.1159/00034144422832383
   PubMedGoogle Scholar
• Xiao X, Man A, Shi WD, et al. Effects of matrine on proliferation and apoptosis of breast cancer SK-BR-3 cells. Shandong Med J. 2018;58:24–27.
   Google Scholar
• Yu M, Cao F, Zhu R, Ding HZ. Effect of ZIC1 associated with matrine on proliferation, migration and apoptosis in MDAMB-231 human breast cancer cell line. Mod Oncol. 2016;24:1528–1533.
   Google Scholar
• Zhou BG, Wei CS, Zhang S, Zhang Z, Wang J. The matrine reverse multidrug resistance on breast cancer MCF-7/ADR cell line and have an influence on downstream factors of PI3K/AKT signal pathway. Mod Oncol. 2017;25:9–13.
   Google Scholar
• Wei CS, Shen YJ, Zhang Z, Wang J, Zhou BG. Matrine reverses multidrug resistance in breast cancer drug-resistant cell line MCF-7/ADR through inhibiting PI3K/AKT signal pathway. J Third Mil Med Univ. 2014;36:2254–2258.
   Google Scholar
• Li HY, Chen Y, He QY. Mechanism of combination of matrine and tetrandrine for reversal of multidrug resistance of breast carcinoma MCF-7 cells. Chin J Exp Tradit Med Formulae. 2013;19:275–278.
   Google Scholar
• Lao YQ. Effect of matrine injection on preventing liver function damage for breast cancer with chemotherapy. J Chin Med Mater. 2005;28:735–737.
   Google Scholar
• Zhou YJ, Guo YJ, Yang XL, Ou ZL. Anti-cervical cancer role of matrine, oxymatrine and sophora flavescens alkaloid gels and its mechanism. J Cancer. 2018;9:1357–1364. doi:10.7150/jca.2242729721044
   PubMed Web of Science ®Google Scholar
• Halim CE, Xinjing SL, Fan L, et al. Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism(s) in tumor models. Pharmacol Res. 2019;147:104327. doi:10.1016/j.phrs.2019.10432731283981
   PubMed Web of Science ®Google Scholar
• Zhou G, Sun J, Fan YZ, Su G. Oxymatrine induces Apoptosis in MCF-7 breast cancer cells. Chin Pharmacol Bull. 2002;11:689–691.
   Google Scholar
• Cai JQ, Wei XX, Huang XX, Zhuang J, Sun H. Oxymatrine inhibits invasion and metastasis of human breast cancer cells in vitro through regulating epithelial-mesenchymal transition. Chin J Clin Pharmacol Ther. 2018;23:13–17.
   Google Scholar
• Wu J, Cai Y, Li M, Zhang Y, Li H, Tan Z. Oxymatrine promotes S-Phase arrest and inhibits cell proliferation of human breast cancer cells in vitro through mitochondria-mediated apoptosis. Biol Pharm Bull. 2017;40:1232–1239. doi:10.1248/bpb.b17-0001028769005
   PubMed Web of Science ®Google Scholar
• Lin B, Li D, Zhang L. Oxymatrine mediates Bax and Bcl-2 expression in human breast cancer MCF-7 cells. Pharmazie. 2016;71:154–157.27183711
   PubMed Web of Science ®Google Scholar
• Zhang Y, Piao B, Zhang Y, et al. Oxymatrine diminishes the side population and inhibits the expression of beta-catenin in MCF-7 breast cancer cells. Med Oncol. 2011;28(Suppl 1):S99–S107. doi:10.1007/s12032-010-9721-y21069479
   PubMedGoogle Scholar
• Zhang Y, Zhu XY, Xu WR, Pei YX, Lin HS. The research of Oxymatrine inhibits the proliferation of human breast cancer MCF-7 cells. Mod Oncol. 2014;22:494–497.
   Google Scholar
• Zhang Y, Zhu XY, Xu WR, Pei YX, Lin HS. Oxymatrine diminished the side population and inhibited Wnt/β-catenin signaling pathway in MCF-7 breast cancer cells. Chin J Integr Med. 2016;36:1504–1509.
   Google Scholar
• Lv JY, Zhao Y. Oxymatrine reverses multidrug resistance on breast cancer MCF-7/ADR cells. China Mod Doctor. 2010;48:86–87.
   Google Scholar
• Chen DL, Wang Q, Li Z. Oxymatrine enhances sensibility of MCF-7 cells to cytotoxicity of NK-92MI cells. Chin J Immunol. 2019;35:680–685.
   Google Scholar
• Albini A, Dell’Eva R, Vene R, et al. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets. FASEB J. 2006;20:527–529. doi:10.1096/fj.05-5128fje16403733
   PubMed Web of Science ®Google Scholar
• Luo H, Rankin GO, Liu L, Daddysman MK, Jiang BH, Chen YC. Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutr Cancer. 2009;61:554–563. doi:10.1080/0163558080266628119838928
   PubMed Web of Science ®Google Scholar
• Priyadarsini RV, Vinothini G, Murugan RS, Manikandan P, Nagini S. The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors. Nutr Cancer. 2011;63:218–226. doi:10.1080/01635581.2011.52350321294050
   PubMed Web of Science ®Google Scholar
• Sun X, Zhuo XB, Hu YP, Zheng X, Zhao QJ. A novel matrine derivative WM622 inhibits hepatocellular carcinoma by inhibiting PI3K/AKT signaling pathways. Mol Cell Biochem. 2018;449:47–54. doi:10.1007/s11010-018-3341-929532226
   PubMed Web of Science ®Google Scholar
• Wu L, Wang G, Liu S, et al. Synthesis and biological evaluation of matrine derivatives containing benzo-alpha-pyrone structure as potent anti-lung cancer agents. Sci Rep. 2016;6:35918. doi:10.1038/srep3591827786281
   PubMed Web of Science ®Google Scholar
• Liu Y, Qi Y, Bai ZH, et al. A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways. Acta Pharmacol Sin. 2017;38:120–132. doi:10.1038/aps.2016.10427773936
   PubMed Web of Science ®Google Scholar
• Yin H, Que R, Liu C, et al. Survivin-targeted drug screening platform identifies a matrine derivative WM-127 as a potential therapeutics against hepatocellular carcinoma. Cancer Lett. 2018;425:54–64. doi:10.1016/j.canlet.2018.03.04429608986
   PubMed Web of Science ®Google Scholar
• Sun M, Han J, Duan J, et al. Novel antitumor activities of Kushen flavonoids in vitro and in vivo. Phytother Res. 2007;21:269–277. doi:10.1002/ptr.206617186494
   PubMed Web of Science ®Google Scholar
• Li X, Zhao WL, Jiang JD, et al. Synthesis, structure-activity relationship and biological evaluation of anticancer activity for novel N-substituted sophoridinic acid derivatives. Bioorg Med Chem Lett. 2011;21:5251–5254. doi:10.1016/j.bmcl.2011.07.03821807514
   PubMed Web of Science ®Google Scholar
• Zhang XL, Cao MA, Pu LP, et al. A novel flavonoid isolated from Sophora flavescens exhibited anti-angiogenesis activity, decreased VEGF expression and caused G0/G1 cell cycle arrest in vitro. Pharmazie. 2013;68:369–375.23802436
   PubMed Web of Science ®Google Scholar
• Bi C, Zhang C, Li Y, et al. Synthesis and biological evaluation of sophoridinol derivatives as a novel family of potential anticancer agents. ACS Med Chem Lett. 2014;5:1225–1229. doi:10.1021/ml500289h25408835
   PubMed Web of Science ®Google Scholar
• Bi C, Ye C, Li Y, Zhao W, Shao R, Song D. Synthesis and biological evaluation of 12-N-p-chlorobenzyl sophoridinol derivatives as a novel family of anticancer agents. Acta Pharmaceutica Sinica B. 2016;6:222–228. doi:10.1016/j.apsb.2016.03.00427175333
   PubMed Web of Science ®Google Scholar
• Jiang L, Wu L, Yang F, et al. Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents. Oncol Lett. 2017;14:3057–3064. doi:10.3892/ol.2017.647528927053
   PubMed Web of Science ®Google Scholar
• Li ZY, Huang WC, Tu RS, Gu RY, Lin CF, Liou CJ. Sophoraflavanone G induces apoptosis in human leukemia cells and blocks MAPK activation. Am J Chin Med (Gard City N Y). 2016;44:165–176. doi:10.1142/S0192415X16500117
   Web of Science ®Google Scholar