366
Views
0
CrossRef citations to date
0
Altmetric
CASE REPORT

Neoadjuvant Radiation Therapy with Interdigitated High-Dose LRT for Voluminous High-Grade Soft-Tissue Sarcoma

, , , , , ORCID Icon & ORCID Icon show all
Pages 113-122 | Received 18 Oct 2022, Accepted 18 Jan 2023, Published online: 05 Feb 2023

Figures & data

Figure 1 LRT plan. Upper left: dose distribution in an axial plane. Upper right: peak-valley dose profiles defined by the red line across the two dose vertices. Lower left: dose distribution in a coronal plane. Lower right: peak-valley dose profiles defined by the red line across the two dose vertices. The dose profiles contain individual arcs (lower 4 curves) and combined-arcs (upper curve).

Figure 1 LRT plan. Upper left: dose distribution in an axial plane. Upper right: peak-valley dose profiles defined by the red line across the two dose vertices. Lower left: dose distribution in a coronal plane. Lower right: peak-valley dose profiles defined by the red line across the two dose vertices. The dose profiles contain individual arcs (lower 4 curves) and combined-arcs (upper curve).

Figure 2 LRT↓EBRT delivery sequence.

Figure 2 LRT↓EBRT delivery sequence.

Figure 3 Tumor size changes over the course of induction RT. X: maximal lateral dimension; Y: maximal vertical dimension.

Figure 3 Tumor size changes over the course of induction RT. X: maximal lateral dimension; Y: maximal vertical dimension.

Figure 4 H&E Histomicrographs. (A) (200X) shows tumor ghost cells (devoid of nuclei with area demonstrating infiltrating lymphocytes). (B) (100X) shows extensive fibrosis and tumor cells undergoing apoptosis with occasional infiltrating lymphocytes. No obvious viable tumor cells are seen in both H&E slides.

Figure 4 H&E Histomicrographs. (A) (200X) shows tumor ghost cells (devoid of nuclei with area demonstrating infiltrating lymphocytes). (B) (100X) shows extensive fibrosis and tumor cells undergoing apoptosis with occasional infiltrating lymphocytes. No obvious viable tumor cells are seen in both H&E slides.

Figure 5 Tumor bed two weeks post surgery.

Figure 5 Tumor bed two weeks post surgery.