Figures & data
Table 1 Characteristics of study population
Figure 1 Frequency of exacerbation with different severities over 2 years.
![](/cms/asset/8226c4b2-d42b-481b-b230-5e5dbdafde64/dcop_a_105454_ilg0001.jpg)
![Figure 1 Frequency of exacerbation with different severities over 2 years.](/cms/asset/362b4b60-23ff-42d1-b2a5-e3a3254900cf/dcop_a_105454_f0001_b.jpg)
Table 2 Comparison of baseline characteristics among patients stratified according to severity of exacerbation
Table 3 Comparison of baseline comorbidities among patients stratified according to severity of exacerbation
Figure 2 Annual changes in FEV1 in three groups of patients over 2 years of follow-up.
Abbreviation: FEV1, forced expiratory volume in 1 second.
![Figure 2 Annual changes in FEV1 in three groups of patients over 2 years of follow-up.](/cms/asset/53183a27-8473-4e8a-9726-0898708a17eb/dcop_a_105454_f0002_b.jpg)
Figure 3 Annual changes in LAA% in three groups of patients over 2 years of follow-up.
Abbreviation: LAA%, ratio of low attenuation area.
![Figure 3 Annual changes in LAA% in three groups of patients over 2 years of follow-up.](/cms/asset/b22c31f1-796c-4484-98f1-e81f18392e15/dcop_a_105454_f0003_b.jpg)
Table 4 Predictors of CAT (minimal clinical important difference; ΔCAT ≥2 per year) increase determined by multivariate logistic regression analysis
Figure 4 Annual changes in CAT scores in three groups of patients over 2 years of follow-up.
Abbreviation: CAT, COPD assessment test.
![Figure 4 Annual changes in CAT scores in three groups of patients over 2 years of follow-up.](/cms/asset/74c55762-c882-4ace-95c7-9ce5ea6e6c6a/dcop_a_105454_f0004_b.jpg)
Figure 5 Annual changes in SGRQ total scores over 2 years of follow-up.
Notes: Patients in the exacerbation-free (••▲••), mild exacerbator (–○–), and moderate/severe exacerbator (–■–) groups. Moderate/severe exacerbator vs exacerbation free, P<0.001; mild exacerbator vs exacerbation free, P=0.041; and mild exacerbator vs moderate/severe exacerbator, P=0.013.
Abbreviation: SGRQ, St George’s Respiratory Questionnaire.
![Figure 5 Annual changes in SGRQ total scores over 2 years of follow-up.Notes: Patients in the exacerbation-free (••▲••), mild exacerbator (–○–), and moderate/severe exacerbator (–■–) groups. Moderate/severe exacerbator vs exacerbation free, P<0.001; mild exacerbator vs exacerbation free, P=0.041; and mild exacerbator vs moderate/severe exacerbator, P=0.013.Abbreviation: SGRQ, St George’s Respiratory Questionnaire.](/cms/asset/a81dbc8e-3cc3-4fb7-8d03-c964f3fdbad4/dcop_a_105454_f0005_b.jpg)
Figure 6 Annual changes in SGRQ symptoms category over 2 years of follow-up.
Notes: Patients in the exacerbation-free (••▲••), mild exacerbator (–○–), and moderate/severe exacerbator (–■–) groups. Moderate/severe exacerbator vs exacerbation free, P<0.001; mild exacerbator vs exacerbation free, P=0.002; and mild exacerbator vs moderate/severe exacerbator, P=1.000.
Abbreviation: SGRQ, St George’s Respiratory Questionnaire.
![Figure 6 Annual changes in SGRQ symptoms category over 2 years of follow-up.Notes: Patients in the exacerbation-free (••▲••), mild exacerbator (–○–), and moderate/severe exacerbator (–■–) groups. Moderate/severe exacerbator vs exacerbation free, P<0.001; mild exacerbator vs exacerbation free, P=0.002; and mild exacerbator vs moderate/severe exacerbator, P=1.000.Abbreviation: SGRQ, St George’s Respiratory Questionnaire.](/cms/asset/130622ee-08ea-420a-b7d2-475c11f18b82/dcop_a_105454_f0006_b.jpg)
Figure 7 Annual changes in SGRQ activity category over 2 years of follow-up.
Notes: Patients in the exacerbation-free (••▲••), mild exacerbator (–○–), and moderate/severe exacerbator (–■–) groups. Moderate/severe exacerbator vs exacerbation free, P<0.001; mild exacerbator vs exacerbation free, P=0.226; and mild exacerbator vs moderate/severe exacerbator, P=0.004.
Abbreviation: SGRQ, St George’s Respiratory Questionnaire.
![Figure 7 Annual changes in SGRQ activity category over 2 years of follow-up.Notes: Patients in the exacerbation-free (••▲••), mild exacerbator (–○–), and moderate/severe exacerbator (–■–) groups. Moderate/severe exacerbator vs exacerbation free, P<0.001; mild exacerbator vs exacerbation free, P=0.226; and mild exacerbator vs moderate/severe exacerbator, P=0.004.Abbreviation: SGRQ, St George’s Respiratory Questionnaire.](/cms/asset/009efa09-a8c5-4a39-bb3c-fafee4723f31/dcop_a_105454_f0007_b.jpg)
Figure 8 Annual changes in SGRQ impact category over 2 years of follow-up.
Abbreviation: SGRQ, St George’s Respiratory Questionnaire.
![Figure 8 Annual changes in SGRQ impact category over 2 years of follow-up.](/cms/asset/5261817b-c506-43a5-8c04-e08185a76bcc/dcop_a_105454_f0008_b.jpg)