A simple and rapid test of physical performance in chronic obstructive pulmonary disease

Figures & data

Table 1 Characteristics of patients with COPD and control subjects

Variable	COPD (n=520)	Control (n=150)	P-value
Sex (male:female)	270:250	76:74	0.451
Age (years)	66.1±7.6	65±7.4	0.109
FEV1/FVC (L)	0.53±0.11	0.78±0.05	<0.001
FEV1 (% predicted)	58±19	105±14	<0.001
FVC (% predicted)	87±21	109±15	<0.001
Smoking (pack-years)	41±25	22±18	<0.001
BMI (kg/m^2)	28.0±5.5	28.1±4.1	0.951
Waist circumference (cm)	99.6±15.0	94.7±10.2	0.001
Hip circumference (cm)	104.2±11.0	105.0±8.7	0.250
Fat %	34.1±8.4	33.3±7.8	0.345
FFMI (kg/m^2)	18.1±2.6	18.5±2.3	0.097
Handgrip (kg)	27.1±9.7	31.3±10.3	<0.001
TUG (seconds)	11.5±4	8.3±1.2	<0.001
6MWD (m)	335±125	502±85	<0.001
Resting O2 saturation (%)	97±2	98±1	<0.001
Fibrinogen (g/L)#	3.51±1.31	3.08±1.25	<0.001
CRP (mg/ml)#	3.49±2.89	1.76±3.18	<0.001
No exacerbations/year*	2 (1–3)	–	–
SGRQ total*	53 (36–68)	–	–
CAT score*	21 (14–27)	–	–

Notes: All data are mean (SD) unless otherwise indicated.

* Represents median (range) and

# represents geometric mean.

Abbreviations: 6MWD, 6-minute walk distance; BMI, body mass index; CAT, COPD assessment test; COPD, chronic obstructive pulmonary disease; CRP, C-reactive protein; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; FFMI, fat-free mass index; SD, standard deviation; SGRQ, St George’s Respiratory Questionnaire; TUG, timed up and go; –, not applicable.

Figure 1 TUG test across age categories in COPD and control subjects.

Note: *P<0.001.
Abbreviations: COPD, chronic obstructive pulmonary disease; ROC, receiver operating characteristic; TUG, timed up and go.

Table 2 Relationships between timed up and go test and other variables in patients and controls

Variable	COPD	P-value	Control	P-value
Age (years)	0.18	0.005	0.22	0.001
FEV1% predicted	−0.19	0.001	−0.04	0.610
Resting O2 saturation (%)	−0.12	0.005	−0.002	0.977
mMRC	0.34	0.001	–	–
6MWD (m)	−0.71	0.001	0.38	0.001
HGS (kg)	−0.27	0.001	−0.02	0.833
BMI (kg/m^2)	0.24	0.001	0.20	0.018
FM (kg)	0.21	0.001	0.12	0.141
FMI (kg/m^2)	0.21	0.001	0.12	0.144

Abbreviations: 6MWD, 6-minute walk distance; BMI, body mass index; COPD, chronic obstructive pulmonary disease; HGS, handgrip strength; FEV₁, forced expiratory volume in 1 second; FM, fat mass; FMI, fat mass index; mMRC, modified Medical Research Council; –, not applicable.

Figure 2 The ROC curve for the TUG test.

Note: Diagnostic ability of TUG test in patients with COPD.
Abbreviations: COPD, chronic obstructive pulmonary disease; ROC, receiver operating characteristic; TUG, timed up and go.