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Original Research

An in silico analysis of oxygen uptake of a mild COPD patient during rest and exercise using a portable oxygen concentrator

, , , , , , , , & show all
Pages 2427-2434 | Published online: 29 Sep 2016

Figures & data

Figure 1 Eclipse 5 portable oxygen concentrator connected to the test system.

Figure 1 Eclipse 5 portable oxygen concentrator connected to the test system.

Figure 2 Output flow curves for setting 1, fast and medium pulse, obtained from the test system for the Eclipse 5 POC.

Notes: The nominal delay and width times are indicated by the arrows; measured times are defined as the time from the beginning of the negative pressure signal until the flow begins and the time measured from the beginning of the pulse to the time that the flow falls <0.2 L/min, respectively.
Abbreviation: POC, portable oxygen concentrator.
Figure 2 Output flow curves for setting 1, fast and medium pulse, obtained from the test system for the Eclipse 5 POC.

Table 1 Characteristics of the in silico healthy and the COPD disease models

Table 2 Average values of pulse volume, pulse width, and pulse delay of ten measurements

Table 3 Oxygenation results

Figure 3 The percentage efficiency of therapy under each condition/setting combination, where the efficiency is the percentage of oxygen provided by the device that is taken up by the blood.

Abbreviations: cont, continuous; med, medium.
Figure 3 The percentage efficiency of therapy under each condition/setting combination, where the efficiency is the percentage of oxygen provided by the device that is taken up by the blood.

Figure 4 Individualized, 3D deterministic model of the conducting part of the human tracheo-bronchial tree.

Notes: For clarity, the branching structure is only shown in the right and left upper lobes. A complete lung structure model will allow for accurate determination of the pulse arrival time at each individual acinus.

Figure 4 Individualized, 3D deterministic model of the conducting part of the human tracheo-bronchial tree.Notes: For clarity, the branching structure is only shown in the right and left upper lobes. A complete lung structure model will allow for accurate determination of the pulse arrival time at each individual acinus.

Figure 5 Arrival time at the acini in lung model for two healthy volunteers with tidal volume of 600 mL, inhalation time of 2 seconds, and for an inspiratory flow rate of 18 L/min.

Notes: Total number of acini were 15,952 for subject H01 and 28,255 for subject H03. The intersubject and intrasubject variabilities in arrival time to the acini will influence the efficiency oxygen uptake for a given pulse setting.
Figure 5 Arrival time at the acini in lung model for two healthy volunteers with tidal volume of 600 mL, inhalation time of 2 seconds, and for an inspiratory flow rate of 18 L/min.