Figures & data
Table 1 Baseline characteristics
Figure 1 Study flow diagram.
Table 2 Symptom burden, exercise capacity, body composition, vascular function, and capillarization
Figure 2 Fiber-type change.
Notes: (A and B) Representative skeletal muscle cross-sections after immunohistochemistry were performed using antibodies against myosin heavy chain (MHC) type I (green), MHC IIa (red) seen under a light microscope ×10 objective. White scale bars=100 µm. Muscle sections from two participants before and after (A) ET and (B) RT. (C and D) Mean values of fiber-type proportions (%) with error bars (SD) in the ET group and the RT group. #Significant difference within training group (paired t-test): P<0.05, *significant difference between groups (Student’s t-test of mean change from baseline): P<0.05.
Abbreviations: ET, endurance training; MHC, myosin heavy chain; RT, resistance training.
Abbreviations: ET, endurance training; MHC, myosin heavy chain; RT, resistance training.
Figure 3 Muscle protein content.
Notes: Representative Western blots of (A) PFK, (B) CS, and GAPDH protein content in skeletal muscle from six COPD participants (#1–6). Samples from the same participant were loaded side by side before (indicated as b) and after (indicated as a) ET and RT.
Abbreviations: CS, citrate synthase; ET, endurance training; PFK, phosphofructokinase; RT, resistance training.
Abbreviations: CS, citrate synthase; ET, endurance training; PFK, phosphofructokinase; RT, resistance training.
Figure 4 Leg muscle blood flow.
Notes: Leg blood flow (L/min) during 1 minute of passive leg movements followed by 3 minutes of leg kicking (12 W) in (A) the RT group, (B) the ET group, and (C) all subjects before and after the training intervention. Data are presented as mean ± standard error of mean. *Different from before training: P<0.05 (two-way ANOVA with repeated measures and Holm-Sidak post hoc).
Abbreviations: ET, endurance training; RT, resistance training.
Abbreviations: ET, endurance training; RT, resistance training.
