IL-26 in the induced sputum is associated with the level of systemic inflammation, lung functions and body weight in COPD patients

Figures & data

Table 1 Characteristics of the studied population

Characteristics	Healthy subjects (n=17)	Non-obese COPD patients (n=30)	Obese COPD patients (n=53)	P-value
Age, years	52.65±8.68	57.17±8.27	56.75±7.58	ns
Male/female (n)	10/7	23/7	38/15	ns
Weight, kg	66.76±6.37	68.11±6.68	96.30±9.41	0.0001* 0.0001**
Height, m	1.72±0.05	1.72±0.06	1.70±0.08	ns
BMI, kg/m^2	22.63±1.45	23.08±1.32	33.48±2.5	0.0001* 0.0001**
Pack-years	–	24.05±6.76	21.72±7.11	ns
FEV1, %	81.93±5.24	63.10±3.61*	59.11±4.77	0.0001* 0.0001**
FEV1/FVC, %	78.71±5.29	66.67±2.35*	62.47±3.85	0.0001* 0.0001**

Notes: Data are presented as mean ± SD.

* Difference between healthy patients and patients with COPD;

** difference between non-obese and obese COPD patients.

Abbreviations: BMI, body mass index; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; ns, not significant.

Figure 1 Biomarkers concentration in the biological fluids from populations investigated: (A) IL-26 in induced sputum; (B) CRP level in serum; (C) leptin level in serum.

Abbreviations: CRP, C-reactive protein; IL, interleukin.

Figure 2 Correlation analysis (A) IL-26 with BMI; (B) CRP with BMI; (C) leptin with BMI; (D) IL-26 with CRP; (E) IL-26 with leptin; (F) leptin with CRP.

Abbreviations: BMI, body mass index; CRP, C-reactive protein; IL, interleukin.

Figure 3 Correlation analysis (A) IL-26 with FEV₁; (B) CRP with FEV₁; (C) leptin with FEV₁; (D) IL-26 with FEV₁/FEV; (E) CRP with FEV₁/FVC; (F) leptin with FEV₁/FEV.

Abbreviations: CRP, C-reactive protein; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; IL, interleukin.