Blood eosinophils and inhaled corticosteroids in patients with COPD: systematic review and meta-analysis

Figures & data

Table 1 Summary of five articles from PubMed and EMBASE that were determined eligible using the keywords “COPD”, “eosinophil”, and “clinical trial” based on systematic review criteria

No	Author	Year	Title	Study arms	Subgroup
1	Barnes et al^Citation29	2016	Blood eosinophils as a marker of response to ICS in COPD	FP vs placebo	Eos count: <2% and ≥2%
2	Pascoe et al^Citation27	2015	Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with COPD: a secondary analysis of data from two parallel randomised controlled trials	FP/SAL vs tiotropium	Eos count: <2% and ≥2%
Pascoe et al 2015 (appendix)			FP/SAL with its monocomponents and placebo
Appendix			FP/SAL with FP and placebo
3	Pascoe et al^Citation27	2015	Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with COPD: a secondary analysis of data from two parallel randomised controlled trials	Fluticasone furoate + vilanterol vs vilanterol alone	Eos count: <2% and ≥2%
4	Roche et al^Citation32	2017	Blood eosinophils and response to maintenance COPD treatment	Indacaterol glycopyrronium vs fluticasone salmeterol	Eos count: <2% and ≥2% <3% and ≥3% <5% and ≥5%
5	Watz et al^Citation31	2016	Blood eosinophil count and exacerbations in severe COPD after withdrawal of ICS: a post-hoc analysis of the WISDOM trial	ICS continuation vs ICS withdrawal	Eos count: <2% and ≥2%

Abbreviations: Eos, eosinophil; ICS, inhaled corticosteroid; FP, fluticasone propionate; SAL, salmeterol.

Figure 1 Forest plots of studies comparing the pooled risk ratio for moderate/severe exacerbation in patients with COPD receiving ICS-containing treatment or non-ICS/ICS withdrawal/placebo treatments by subgroup.

Note: (A) Eosinophil counts <2% and (B) eosinophil counts ≥2%.

Abbreviation: ICS, inhaled corticosteroid.

Figure 2 Analysis of publication bias for pooled risk ratio of moderate/severe exacerbation for (A) eosinophil counts <2% and (B) eosinophil counts ≥2%.

Figure 3 Forest plots of studies comparing the pooled hazard ratio for time-to-first moderate/severe exacerbation in patients with COPD receiving ICS-containing treatment or non-ICS/ICS withdrawal/placebo treatments by subgroup.

Note: (A) Eosinophil counts <2% and (B) eosinophil counts ≥2%.

Abbreviation: ICS, inhaled corticosteroid.

Figure 4 Forest plots of studies comparing the pooled relative risk of pneumonia events in patients with COPD receiving ICS-containing treatment or non-ICS/ICS withdrawal/placebo treatments by subgroup.

Note: (A) Eosinophil counts <2% and (B) eosinophil counts ≥2%.
Abbreviation: ICS, inhaled corticosteroid.

BarnesNCSharmaRLettisSCalverleyPMBlood eosinophils as a marker of response to inhaled corticosteroids in COPDEur Respir J20164751374138226917606

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PascoeSLocantoreNDransfieldMTBarnesNCPavordIDBlood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trialsLancet Respir Med20153643544225878028

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RocheNChapmanKRVogelmeierCFBlood eosinophils and response to maintenance chronic obstructive pulmonary disease treatment. Data from the FLAME trialAm J Respir Crit Care Med201719591189119728278391

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WatzHTetzlaffKWoutersEFBlood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trialLancet Respir Med20164539039827066739

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