Serum endocan levels in patients with stable COPD

Figures & data

Table 1 Differences between COPD patients and controls

Characteristics	COPD patients (n=47)	Control subjects (n=41)	P-value
Age (years)	61.5±8.7	59.7±9.7	0.4
	Range: 40–75	Range: 43–79
Gender (female/male)	4/43	3/38	0.9
BMI (kg/m^2)	25.0±2.9	26.0±1.9	0.06
Smoking history (pack years)	36.3±17.2	30.0±20.1	0.09
Comorbidities (%) (hypertension and/or diabetes)	25.5	19.5	0.6
Endocan level (pg/mL)	860.1±259.9	647.3±316.9	0.001

Abbreviations: BMI, body mass index; Endocan, endothelial cell specific molecule-1.

Figure 1 The distribution of endocan levels in COPD patients and control subjects.

Table 2 Comparison of COPD GOLD categories

Characteristics	COPD group B (n=18)	COPD group C (n=14)	COPD group D (n=15)	P-value
Age (years)	60.5±9.1	63.4±9.1	60.9±9.8	0.6
Gender (female/male)	2/16	0/14	2/13	0.3
BMI (kg/m^2)	26.4±2.2	24.7±2.4	23.7±3.3	0.01
Smoking (pack years)	33.4±14.7	33.6±15.6	43.3±21.0	0.3
FEV1 (%)	62.0±6.0	36.1±11.7	29.7±11.5	<0.001
FVC (%)	74.4±8.2	52.9±12.3	44.9±16.9	<0.001
PaO2 (mmHg)	76.7±6.3	68.7±12.3	61.0±1.0	<0.001
PaCO2 (mmHg)	39.1±4.0	44.9±7.6	51.2±9.2	<0.001
Comorbidities (%)	22.2	42.9	13.3	0.2
Endocan level (pg/mL)	820.9±280.8	867.6±236.8	900.3±265.2	0.6

Abbreviations: BMI, body mass index; FEV₁, forced expiratory volume 1 second; FVC, forced vital capacity; GOLD, Global Initiative for Chronic Obstructive Lung Disease; PaCO₂, partial arterial carbon dioxide pressure; PaO₂, partial arterial oxygen pressure.

Table 3 Differences between COPD patients with and without significant hypoxemia

Characteristics	With hypoxemia (n=17)	Without hypoxemia (n=30)	P-value
Age (years)	61.8±10.0	61.3±8.2	0.9
Gender (female/male)	2/15	2/28	0.2
BMI (kg/m^2)	23.7±3.3	25.8±2.3	0.03
Smoking (pack/years)	37.1±18.2	35.9±17.0	0.2
FEV1 (%)	29.8±10.8	52.0±15.3	<0.001
FVC (%)	44.3±15.0	66.6±14.2	<0.001
PaO2 (mmHg)	59.1±9.8	75.0±7.6	<0.001
PaCO2 (mmHg)	52.7±8.3	40.1±4.2	<0.001
Comorbidities (%)	11.8	33.3	0.2
Endocan level (pg/mL)	921.2±252.0	825.5±262.0	0.2

Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume 1 second; FVC, force vital capacity; PaCO₂, partial arterial carbon dioxide pressure; PaO₂, partial arterial oxygen pressure.

Table 4 Differences between COPD patients with and without comorbidities

Characteristics	With comorbidities (n=12)	Without comorbidities (n=35)	P-value
Age (years)	66.8±4.9	59.6±9.0	0.01
Gender (female/male)	1/11	3/32	0.9
BMI (kg/m^2)	25.9±2.5	24.7±2.9	0.2
Smoking (pack years)	37.0±16.5	36.1±17.6	0.8
FEV1 (%)	43.6±15.4	44.1±18.4	0.9
FVC (%)	58.7±16.6	58.5±18.7	0.9
PaO2 (mmHg)	72.8±11.1	67.1±12.6	0.7
PaCO2 (mmHg)	41.3±5.1	45.8±9.1	0.1
LTOT (%)	16.7	42.9	0.2
NIMV (%)	8.3	25.7	0.4
Endocan level (pg/mL)	910.8±207.3	842.8±276.2	0.4

Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume 1 second; FVC, forced vital capacity; LTOT, long-term oxygen therapy; NIMV, noninvasive mechanical ventilation; PaCO₂, partial arterial carbon dioxide pressure; PaO₂, partial arterial oxygen pressure.