Figures & data
Table 1 Comparisons of baseline characteristics suggested the credibility of %LAA-950-dependent grouping method
Table 2 Forty-five DEGs were identified between severe and mild emphysema groups
Table 3 Known driver genes of COPD as grouped into four categories
Figure 1 Candidate genes were screened by direct PPi of DEGs and COPD driver genes.
Notes: The left panel shows the 147 genes-constructed interaction network. Eight driver genes-associated DEGs are highlighted at the center of circle and the red lines identify the interaction relationship of the eight highlighted DEGs and the corresponding driver genes. The right panel amplifies the mutual relationship of eight DEGs and their interacted COPD driver genes.
Abbreviations: DEGs, differentially expressed genes; PPi, protein–protein interaction.
Abbreviations: DEGs, differentially expressed genes; PPi, protein–protein interaction.
Figure 2 Common key genes are screened by merging of indirect PPi and driver PPi.
Notes: The left panel represents the 125 driver genes-constructed interaction network, and the right panel shows the 375 genes-constructed network of first-layer proteins of DEGs. The top three genes in the rank of topological network node stand out at the center of right circle and the red lines identify their interaction relationship with other first-layer proteins. The upper panel shows the merge network of the lower two PPis, representing the common genes and pathways involved in the two networks.
Abbreviations: DEGs, differentially expressed genes; PPi, protein–protein interaction.
Abbreviations: DEGs, differentially expressed genes; PPi, protein–protein interaction.
Table S1 GO annotation of DEGs between severe and mild emphysema groups
Table S2 The list of first-layer interacting proteins associated with DEGs between two groups
Table S3 Top 20 topological network nodes in first-layer’s PPi
Table S4 Transcript factors of common key genes screened by indirect PPi