Nasal high-flow in acute hypercapnic exacerbation of COPD

Figures & data

Table 1 Parameters during NHF treatment

Parameters	All patients (pH ≤7.38; n=38)
	Baseline (mean±SD)	End (mean±SD)	Change (mean±SD)	P-value
pH	7.339±0.041	7.392±0.048	0.052±0.048	0.000
pCO2 mmHg	67.6±12.9	58.5±9.7	−9.1±8.8	0.001
pO2 mmHg	58.3±15.2	58.3±17.6	–	0.983
SO2 %	85.3±9.5	86.2±11.3	–	0.798
HCO3 mmol/L	30.8±5.1	31.6±5.3	–	0.636
Base excess mmol/L	6.9±4.9	7.7±5.4	–	0.633
NHF flow L/min	–	25.8±8.2	–	–
Treatment time min	–	195±231	–	–
	Patients with pH <7.35 (n=17)
pH	7.298±0.046	7.379±0.051	0.082±0.060	0.000
pCO2 mmHg	73.7±13.7	59.6±11.2	−14.2±10.6	0.002
pO2 mmHg	56.9±14.8	55.6±20.7	–	0.845
SO2 %	84.8±10.1	84.3±11.9	–	0.904
HCO3 mmol/L	31.6±5.5	32.5±5.6	–	0.661
Base excess mmol/L	7.4±5.3	8.5±5.7	–	0.591
NHF flow L/min	–	26.3±7.9	–	–
Treatment time min	–	252±251	–	–

Notes: Changes in blood gas analyses data, usage time and flow rates during NHF therapy in all patients and in the subgroup with pH <7.35. All data are organized as mean±SD. “–” indicates no significant differences to report.

Abbreviation: NHF, nasal high-flow.

Figure 1 Changes in pH and paCO₂ in all patients; the bold line marks mean values; P<0.05.