Assisted ventilation in COPD – association between previous hospitalizations and mortality

Figures & data

Figure 1 The inclusion of patients.

Table 1 Characteristics of included patients at baseline by number of COPD hospitalizations in the previous year

Characteristics	Number of admissions in the previous year
	0	1	2	3+	Total
	n=4,333	n=1,213	n=538	n=572	n=6,656
Sex
Male	2,481 (57.3%)	684 (56.4%)	305 (56.7%)	320 (55.9%)	3,790 (56.9%)
Age, year
Median (IQR)	74.1 (66.4–79.8)	74.8 (67.5–80.6)	73.9 (67.1–80.0)	72.9 (65.1–77.9)	74.1 (66.5–79.8)
Charlson comorbidity score
1	1,691 (39.0%)	429 (35.4%)	183 (34.0%)	216 (37.8%)	2,519 (37.8%)
2	1,051 (24.3%)	278 (22.9%)	131 (24.3%)	150 (26.2%)	1,610 (24.2%)
3+	1,591 (36.7%)	506 (41.7%)	224 (41.6%)	206 (36.0%)	2,527 (38.0%)
Time period
2003–2005	856 (19.8%)	247 (20.4%)	120 (22.3%)	133 (23.3%)	1,356 (20.4%)
2006–2008	1,410 (32.5%)	412 (34.0%)	181 (33.6%)	191 (33.4%)	2,194 (33.0%)
2009–2011	2,067 (47.7%)	554 (45.7%)	237 (44.1%)	248 (43.4%)	3,106 (46.7%)
Mode of ventilation
NIV	2,316 (53.5%)	726 (59.9%)	346 (64.3%)	389 (68.0%)	3,777 (56.7%)
Length of stay
1–2 days	406 (9.4%)	126 (10.4%)	81 (15.1%)	64 (11.2%)	677 (10.2%)
3–7 days	1,023 (23.6%)	333 (27.5%)	157 (29.2%)	178 (31.1%)	1,691 (25.4%)
7+ days	2,904 (67.0%)	754 (62.2%)	300 (55.8%)	330 (57.7%)	4,288 (64.4%)

Abbreviations: IQR, interquartile rage; NIV, noninvasive mechanical ventilation.

Table 2 In-hospital mortality by number of COPD hospitalizations in the previous year

	Number of admissions in the previous year
	0	1	2	3+	Total
	n=4,333	n=1,213	n=538	n=572	n=6,656
Mortality, n (%)
Death before discharge	1,832 (42%)	585 (48%)	270 (50%)	286 (50%)	2,973 (45%)

Table 3 Mortality after discharge by number of COPD hospitalizations in the previous year

	Number of admissions in the previous year
	0	1	2	3+	Total
	n=2,501	n=628	n=268	n=286	n=3,683
Mortality
Death within 30 days	236 (9%)	99 (16%)	41 (15%)	44 (15%)	420 (11%)
Death within 1 year	827 (33%)	296 (47%)	158 (59%)	169 (59%)	1,450 (39%)

Figure 2 Logistic regression model of in-hospital mortality.

Note: *Significant at P<0.05.
Abbreviations: NIV, noninvasive mechanical ventilation; IMV, invasive mechanical ventilation.

Figure 3 Cox proportional hazards model of mortality after discharge.

Note: *indicates significant at P<0.05.
Abbreviations: NIV, noninvasive mechanical ventilation; IMV, invasive mechanical ventilation.

Figure 4 Respiratory hospitalizations.

Notes: (A) Logistic regression model of in-hospital mortality, (B) Cox proportional hazards model of mortality after discharge. *indicates significant at P<0.05.
Abbreviations: NIV, noninvasive mechanical ventilation; IMV, invasive mechanical ventilation.