Advances in the management of glioblastoma: the role of temozolomide and MGMT testing

Figures & data

Figure 1 MTIC, the active metabolite of TMZ, adds a methyl group to guanine which causes a base pair mismatch.

Notes: This leads either to repair and continued DNA replication, or programed cell death. AGT, the enzyme that repairs damage caused by TMZ, is a “suicide” enzyme (it can be used only once per mismatch repair) and therefore can be overwhelmed.
Abbreviations: AGT, O⁶-alkylguanine-DNA alkyltransferase; MGMT, O⁶-methylguanine-DNA methyltransferase; MTIC, 5-(3-methyltriazen-1yl)-imidazole-4-carboxamide; TMZ, temozolomide.

Figure 2 The bisulfite reaction is the first step in detection of MGMT methylation status for both gel-based and real-time polymerase chain reaction.

Abbreviation: MGMT, O⁶-methylguanine-DNA methyltransferase.

Figure 3 MGMT status has a significant impact on overall survival in glioblastoma patients.

Abbreviation: MGMT, O⁶-methylguanine-DNA methyltransferase.

ChangCHHortonJSchoenfeldDComparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group studyCancer198352699710076349785

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