Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting

Figures & data

Figure 1 Transport routes across the blood–brain barrier.

Note: Green lines indicate tight junctions; blue boxes indicate no carrier or receptor mediated transport.
Abbreviations: BBB, blood–brain barrier; RMT, receptor-mediated transcytosis; AMT, adsorptive-mediated transcytosis.

Figure 2 Graphic description of nasal mucosa graft.

Notes: The area circled in red indicates the nasal mucosal grafting area; the green arrow indicates absorption direction; and the white boxed area indicates removed bone and dura/arachnoid.

Figure 3 Schematic representation of therapeutic approaches to LSDs.

Abbreviations: LSDs, lysosomal storage diseases; ERT, enzyme replacement therapy.