Figures & data
Abbreviations: HLB, hydrophilic lipophilic balance; ERL, Eudragit RLPO; X1, ERL loading percentage; X2, emulsifier HLB; X3, talc percentage; X4, dispersed phase volume; X1X2, X1X3, X1X4, X2X3, X2X4, and X3X4 are the interaction terms between the factors; X1X1, X2X2, X3X3, and X4X4 are the quadratic terms between the factors.
Abbreviations: HLB, hydrophilic lipophilic balance; ERL, Eudragit RLPO; D-LSCD, Draper–Lin small composite design; X1, ERLloading percentage; X2, emulsifier HLB; X3, talc percentage; X4, dispersed phase volume; X1X2, X1X3, X1X4, X2X3, X2X4, and X3X4 are the interaction terms between the factors; X1X1, X2X2, X3X3, and X4X4 are the quadratic terms between the factors; Y1, particle size; Y2, angle of repose; Y3, production yield; Y4, encapsulation efficiency; Y5, loading capacity; Y6, initial release; Y7, time for 85% of drug release.
Notes: (A) Correlation between talc% and both particle size and angle of repose, (B) correlation between Eudragit RLPO loading% and both the initial release% and the time for 85% of drug release, (C) correlation between the emulsifier HLB and both the encapsulation efficiency and the loading capacity, and (D) correlation between the dispersed phase volume and both the encapsulation efficiency and the loading capacity.
Abbreviations: HLB, hydrophilic lipophilic balance; ERL, Eudragit RLPO; EE, encapsulation efficiency; LC, loading capacity; T85%, time for 85% of drug release.
Abbreviations: HLB, hydrophilic lipophilic balance; ERL, Eudragit RLPO; EE, encapsulation efficiency; LC, loading capacity; T85%, time for 85% of drug release.