Figures & data
Table 1 The independent variables of the full factorial design for optimization of AGM-loaded SLNs
Table 2 The dependent variables of the full factorial design for optimization of AGM-loaded SLNs
Table 3 The PS and EE of AGM-loaded SLN formulations prepared using different types of lipids
Figure 1 Release profiles of formulations prepared using different lipid concentrations in phosphate buffer (pH 6.8) and at 37°C.
Table 4 Experimental runs, independent variables and measured responses of the full factorial experimental design of AGM-loaded SLNs
Figure 2 Release profiles of AGM-loaded SLNs (A) SLN-1 to SLN-4, (B) SLN-5 to SLN-8, (C) SLN-9 to SLN-12 and (D) SLN-13 to SLN-16 in phosphate buffer (pH 6.8) and at 37°C.
Table 5 Composition and numerical desirability of the full factorial design formulae
Table 6 The observed and observed responses of the optimized formula SLN-14
Figure 3 Transmission electron micrograph of the optimized formula.
Figure 4 DSC thermogram of AGM, PVA, SDC, Gelucire 43/01 and 1:1 physical mixtures of AGM with each of them.
Figure 5 DSC thermogram of AGM and the optimized formula SLN-14.
Table 7 Pharmacokinetic parameters in rat plasma and brain for AGM following IN administration of SLN-14, IV administration of AGM solution and oral administration of Valdoxan® suspension
Figure 6 Plasma concentration vs time curves after administration of SLN-14, IV AGM solution and oral suspension of Valdoxan®.
Figure 7 Brain concentration vs time curves after administration of SLN-14, IV AGM solution and oral suspension of Valdoxan®.
