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Original Research

Hyaluronic acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

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Pages 3501-3507 | Published online: 25 Oct 2016

Figures & data

Figure 1 The surgical technique for creating the adhesion model.

Notes: (A) After a 3 cm incision was made, the uterus was externalized; (B) the uterus was incised and then sutured; (C) an agent (ORC) was then injected into the abdominal cavity; (D) the abdominal wall was closed.
Figure 1 The surgical technique for creating the adhesion model.

Figure 2 The representative adhesions after the first surgery (AD) and second surgery (EH).

Notes: (A) The adhering zone between the gastrocolic omentum and the abdominal wall; (B) the adhering zone between the gastrocolic omentum and the uterus; (C) the adhering zone between the uterus and the abdominal wall; (D) complicated and tight adhesions or internal organs sticking to the abdominal wall; (E) no adhesion; (F) the adhering zone between the gastrocolic omentum and the uterus; (G) the adhering zone between the gastrocolic omentum and the uterus; (H) the adhering zone between the gastrocolic omentum and the abdominal wall.
Figure 2 The representative adhesions after the first surgery (A–D) and second surgery (E–H).

Figure 3 The adhesion scores of the control, ORC, and MSH groups at 2 weeks after first or second surgery.

Abbreviations: ORC, oxidized regenerated cellulose; MSH, medical sodium hyaluronate.
Figure 3 The adhesion scores of the control, ORC, and MSH groups at 2 weeks after first or second surgery.

Figure 4 The body weights in each group are depicted.

Notes: At day 1, the body weights in the control, MSH, and ORC groups were 242.8±6.8, 242.3±5.0, and 240.5±6.6 g, respectively. On day 14, the body weights in the control, MSH, and ORC groups were 224.9±7.1, 238.0±12.1, and 239.6±12.1 g, respectively. On day 28, the body weights in the control, ORC, and MSH groups were 189.3±7.8, 245.5±9.0, and 241.9±6.7 g, respectively.
Abbreviations: ORC, oxidized regenerated cellulose; MSH, medical sodium hyaluronate.
Figure 4 The body weights in each group are depicted.

Figure 5 Hematoxylin–eosin staining of representative adhesion formation.

Notes: Adhesion formation in the uterus–abdominal wall and the omentum–abdominal wall at 2 weeks after the first surgery (A, B) and adhesion reformation at 2 weeks after the second surgery (C, D) are depicted, (100×).
Figure 5 Hematoxylin–eosin staining of representative adhesion formation.