Figures & data
Figure 1 Transcriptomics and genetic alteration analyses of cytoskeleton regulators.
Abbreviations: TCGA, The Cancer Genome Atlas; IP, interacting proteins; OR, organizing and biogenesis; P-D, polymerization or depolymerization; CC, cortical cytoskeleton; SP, spindle organization and biogenesis; AX, axon and dendrites formation; FL, filopodia; G, growth cones; LAM, lamellipodia; MV, microvilli; P, pseudopodia; RF, ruffles; CS-S-P, cell shape–size–polarity; CMM, cell motility or migration; M, mitosis; CK, cytokinesis; CA, cytoskeleton adaptors; Cal, calmodulins and calcineurins; G-Prot, G-protein signaling; Kin&Pho, kinases and phosphatases.
![Figure 1 Transcriptomics and genetic alteration analyses of cytoskeleton regulators.](/cms/asset/fe615fcf-5930-4bfa-b011-16e7d618a54d/dddt_a_12166167_f0001_c.jpg)
Figure 2 Transcriptomics data shown as a color code representing fold change in expression of 85 genes grouped into ten groups with abbreviated subgroups, in GBM samples compared to neural stem cells (NSCs).
Abbreviations: GBM, glioblastoma multiforme; IP, interacting proteins; OR, organizing and biogenesis; P-D, polymerization or depolymerization; CC, cortical cytoskeleton; SP, spindle organization and biogenesis; AX, axon and dendrites formation; FL, filopodia; G, growth cones; LAM, lamellipodia; MV, microvilli; P, pseudopodia; RF, ruffles; CS-S-P, cell shape–size–polarity; CMM, cell motility or migration; M, mitosis; CK, cytokinesis; CA, cytoskeleton adaptors; Cal, calmodulins and calcineurins; G-Prot, G-protein signaling; Kin&Pho, kinases and phosphatases.
![Figure 2 Transcriptomics data shown as a color code representing fold change in expression of 85 genes grouped into ten groups with abbreviated subgroups, in GBM samples compared to neural stem cells (NSCs).](/cms/asset/198adbb9-1e6f-440d-b3c1-826f7239c1a0/dddt_a_12166167_f0002_c.jpg)
Figure 3 Transcriptomics and patient survival plots of cytoskeletal regulators.
Abbreviations: GBM, glioblastoma multiforme; IP, interacting proteins; OR, organizing and biogenesis; P-D, polymerization or depolymerization; CC, cortical cytoskeleton; SP, spindle organization and biogenesis; AX, axon and dendrites formation; FL, filopodia; G, growth cones; LAM, lamellipodia; MV, microvilli; P, pseudopodia; RF, ruffles; CS-S-P, cell shape–size–polarity; CMM, cell motility or migration; M, mitosis; CK, cytokinesis; CA, cytoskeleton adaptors; Cal, calmodulins and calcineurins; G-Prot, G-protein signaling; Kin&Pho, kinases and phosphatases.
![Figure 3 Transcriptomics and patient survival plots of cytoskeletal regulators.](/cms/asset/cd2bd237-a429-4703-9d1c-e3e0873968ae/dddt_a_12166167_f0003_c.jpg)
![Figure 3 Transcriptomics and patient survival plots of cytoskeletal regulators.](/cms/asset/50274f7b-eaff-4016-bbcc-220e0eff4567/dddt_a_12166167_f0003a_c.jpg)
![Figure 3 Transcriptomics and patient survival plots of cytoskeletal regulators.](/cms/asset/72861d39-1391-40db-a035-f15f1c138dcb/dddt_a_12166167_f0003b_c.jpg)
Figure 4 Cell viability screen using FDA approved oncology drugs.
Abbreviation: DMSO, dimethyl sulfoxide.
![Figure 4 Cell viability screen using FDA approved oncology drugs.](/cms/asset/066573f4-bf6d-4388-9f48-b023062cde3b/dddt_a_12166167_f0004_c.jpg)
Figure 5 Cell viability analyses of temozolomide and other compounds.
Abbreviations: IC50, half maximal inhibitory concentration; GBM, glioblastoma multiforme; DMSO, dimethyl sulfoxide.
![Figure 5 Cell viability analyses of temozolomide and other compounds.](/cms/asset/62f4a216-1d02-4eee-9376-b5415d37d352/dddt_a_12166167_f0005_b.jpg)
Figure 6 Staining of GBM cells with DAPI, phalloidin, and antiacetylated tubulin antibody after 2 days treatment with DMSO or different compounds.
Abbreviations: GBM, glioblastoma multiforme; DAPI, 4′,6-diamidino-2-phenylindole; DMSO, dimethyl sulfoxide; Ac, antiacetylated.
![Figure 6 Staining of GBM cells with DAPI, phalloidin, and antiacetylated tubulin antibody after 2 days treatment with DMSO or different compounds.](/cms/asset/60808ffc-a2ff-4695-95ae-6780f8d3b82f/dddt_a_12166167_f0006_b.jpg)