Figures & data
Figure 1 Synthesis of phenylthiazole acids.
Abbreviations: DMF, dimethylformamide; rt, room temperature.
![Figure 1 Synthesis of phenylthiazole acids.](/cms/asset/df0d6d47-9d05-48c9-b5a1-cfe3b6c3caa0/dddt_a_12166171_f0001_b.jpg)
Figure 2 Fluorescence polarization (FP)-based PPARγ ligand screening assay of phenylthiazoles.
Abbreviations: PPARγ, peroxisome proliferator-activated receptor gamma; RSG, rosiglitazone.
![Figure 2 Fluorescence polarization (FP)-based PPARγ ligand screening assay of phenylthiazoles.](/cms/asset/e9c7edec-bae3-48fe-bf3d-27ea279b53c8/dddt_a_12166171_f0002_b.jpg)
Table 1 EC50s of phenyl thiazole acids in FP-based PPARγ ligand screening assay
Table 2 The molecular properties and binding energy of selected phenylthiazole acids
Figure 3 The binding modes of agonists with PPARγ. Orange and cyans colors represented RSG and other agonists, respectively.
Abbreviations: PPARγ, peroxisome proliferator-activated receptor gamma; RSG, rosiglitazone.
![Figure 3 The binding modes of agonists with PPARγ. Orange and cyans colors represented RSG and other agonists, respectively.](/cms/asset/8bd57882-0203-4606-9835-cd585a2d8f55/dddt_a_12166171_f0003_c.jpg)
Figure 4 The RMSD of ligands from the starting structure during 25 ns MD simulations.
Abbreviations: RMSD, root mean square deviation; MD, molecular dynamics; PPARγ, peroxisome proliferator-activated receptor gamma; RSG, rosiglitazone.
![Figure 4 The RMSD of ligands from the starting structure during 25 ns MD simulations.](/cms/asset/a0f0fa17-6d72-46bf-894b-b91fcfe83ce7/dddt_a_12166171_f0004_c.jpg)
Figure 5 The binding modes of 4t.
Abbreviations: PPARγ, peroxisome proliferator-activated receptor gamma; MD, molecular dynamics.
![Figure 5 The binding modes of 4t.](/cms/asset/8472b467-4393-4363-9f9e-f2de66c91d09/dddt_a_12166171_f0005_c.jpg)