Figures & data
Table 1 Characteristics of 5FU microemulsion
Figure 1 5FU microemulsion image in TEM.
Abbreviations: 5FU, 5-fluorouracil; TEM, transmission electron microscopy.
![Figure 1 5FU microemulsion image in TEM.](/cms/asset/d10f3263-6650-455e-a7f9-0661044f08ef/dddt_a_12172984_f0001_b.jpg)
Table 2 Physicochemical properties of the drug-free thermosensitive gel and TG-5FU-ME
Table 3 Stability of 5FU microemulsion
Table 4 Stability of TG-5FU-ME
Figure 2 Appearance of 5FU microemulsion.
Abbreviation: 5FU, 5-fluorouracil.
![Figure 2 Appearance of 5FU microemulsion.](/cms/asset/23ba9826-d1d5-4b54-85fe-6de9224ad220/dddt_a_12172984_f0002_c.jpg)
Figure 3 Appearances of TG-5FU-ME.
Abbreviations: RT, room temperature; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion.
![Figure 3 Appearances of TG-5FU-ME.](/cms/asset/c283a578-1116-4c78-9bdc-f2e66ef1160b/dddt_a_12172984_f0003_c.jpg)
Figure 4 Release profiles of 5FU formulations in vitro.
Abbreviations: 5FU, 5-fluorouracil; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion.
![Figure 4 Release profiles of 5FU formulations in vitro.](/cms/asset/61cdce94-3e94-4526-bbc7-e65434d0ad3e/dddt_a_12172984_f0004_c.jpg)
Figure 5 AP to BL (A→B) and BL to AP (B→A) transport of 5FU.
Abbreviations: AP, apical; BL, basolateral; 5FU, 5-fluorouracil; SD, standard deviation.
![Figure 5 AP to BL (A→B) and BL to AP (B→A) transport of 5FU.](/cms/asset/08541315-d653-46b6-a499-d08fe4f1c2f7/dddt_a_12172984_f0005_c.jpg)
Figure 6 Formulation change affects transportation efficacy of 5FU crossing the Caco-2 cell monolayers.
Abbreviations: 5FU, 5-fluorouracil; HBSS, Hank’s buffered salt solution; HPLC, high-performance liquid chromatography; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion; SD, standard deviation.
![Figure 6 Formulation change affects transportation efficacy of 5FU crossing the Caco-2 cell monolayers.](/cms/asset/65189392-e215-4da8-83e1-a56332d841ec/dddt_a_12172984_f0006_c.jpg)
Figure 7 Absorption of 5FU in vitro.
Abbreviations: AP, apical; BL, basolateral; 5FU, 5-fluorouracil; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion; SD, standard deviation.
![Figure 7 Absorption of 5FU in vitro.](/cms/asset/fed56f5f-3b18-4054-be16-ffca9fefa5b3/dddt_a_12172984_f0007_c.jpg)
Figure 8 Rectal retention time.
Abbreviations: 5FU, 5-fluorouracil; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion; cpx, count per second.
![Figure 8 Rectal retention time.](/cms/asset/73d1c2f2-147d-4e35-9eb7-dcfdffb33f8c/dddt_a_12172984_f0008_c.jpg)
Figure 9 Tissue distribution of 5FU.
Abbreviations: 5FU, 5-fluorouracil; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion; SD, standard deviation.
![Figure 9 Tissue distribution of 5FU.](/cms/asset/d24fe4f6-f733-48ee-940e-3ba3ad9f43d8/dddt_a_12172984_f0009_c.jpg)
Figure 10 The morphology of rectal tissues after exposure to 5FU thermosensitive gel and TG-5FU-ME.
Abbreviations: 5FU, 5-fluorouracil; H&E, hematoxylin and eosin; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion.
![Figure 10 The morphology of rectal tissues after exposure to 5FU thermosensitive gel and TG-5FU-ME.](/cms/asset/00709927-59a0-45ca-bfc8-24d78f227cc6/dddt_a_12172984_f0010_c.jpg)