Figures & data
Figure 1 The identification of the triazole compound that activated autophagy.
Abbreviations: ΔC-TBP, C-terminus-truncated TBP; DMSO, dimethyl sulfoxide; EGFP, enhanced green fluorescence protein; h, hours.
![Figure 1 The identification of the triazole compound that activated autophagy.](/cms/asset/5dc13c33-584b-4e75-bcd2-938040baad80/dddt_a_12173017_f0001_c.jpg)
Figure 2 OC-13 activated autophagic flux and dissolved the insoluble Q79-EGFP aggregates.
Abbreviations: D, DMSO; DMSO, dimethyl sulfoxide; EGFP, enhanced green fluorescence protein; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; h, hours.
![Figure 2 OC-13 activated autophagic flux and dissolved the insoluble Q79-EGFP aggregates.](/cms/asset/812d6aa6-949e-4288-af65-6434ff952c4a/dddt_a_12173017_f0002_b.jpg)
Figure 3 Nucleus exclusion and autophagic amelioration of Q79-EGFP aggregates.
Abbreviations: D, DMSO; DAPI, 4′,6-diamidino-2-phenylindole; DMSO, dimethyl sulfoxide; EGFP, enhanced green fluorescence protein; h, hours.
![Figure 3 Nucleus exclusion and autophagic amelioration of Q79-EGFP aggregates.](/cms/asset/4435e37a-815b-4d25-ad78-d4891f377fb0/dddt_a_12173017_f0003_c.jpg)
Figure 4 The autophagy pathway is related to JNK signaling activation.
Abbreviations: Baf A1, bafilomycin A1; D, DMSO; DMSO, dimethyl sulfoxide; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; JNK1/2, c-Jun N-terminal protein kinase 1 and 2; h, hour.
![Figure 4 The autophagy pathway is related to JNK signaling activation.](/cms/asset/b1244839-f0fd-4079-bd9c-be40af732b15/dddt_a_12173017_f0004_b.jpg)
Figure 5 Inhibition autophagy flux blocked clearance of the Q79-EGFP aggregates.
Abbreviations: Baf A1, bafilomycin A1; D, DMSO; DMSO, dimethyl sulfoxide; EGFP, enhanced green fluorescence protein; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; JNK, c-Jun N-terminal protein kinase; 3-MA, 3-methyladenine; h, hour; W/O, without.
![Figure 5 Inhibition autophagy flux blocked clearance of the Q79-EGFP aggregates.](/cms/asset/1b5911a9-1d0d-43a7-b415-21d3e4161956/dddt_a_12173017_f0005_b.jpg)
Figure 6 Inhibition lysosome fusion with autophagosome impaired clearance of the Q79-EGFP aggregates.
Abbreviations: Baf A1, bafilomycin A1; DAPI, 4′,6-diamidino-2-phenylindole; DMSO, dimethyl sulfoxide; EGFP, enhanced green fluorescence protein; 3-MA, 3-methyladenine; h, hour; W/O, without.
![Figure 6 Inhibition lysosome fusion with autophagosome impaired clearance of the Q79-EGFP aggregates.](/cms/asset/73d88881-973d-4c8e-96a4-4c00a620b6a1/dddt_a_12173017_f0006_c.jpg)